| Full text | |
| Author(s): |
Olatunya, Oladele Simeon
[1, 2]
;
Albuquerque, Dulcineia Martins
[1]
;
Santos, Magnun Nueldo Nunes
[3]
;
Kayode, Tolorunju Segun
[4]
;
Adekile, Adekunle
[5]
;
Costa, Fernando Ferreira
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Estadual Campinas, Hematol & Hemotherapy Ctr, Campinas, SP - Brazil
[2] Ekiti State Univ, Coll Med, Dept Paediat, Ado Ekiti, Ekiti State - Nigeria
[3] Univ Estadual Campinas, Sch Med Sci, Dept Clin Pathol, Campinas, SP - Brazil
[4] Ekiti State Univ, Dept Chem Pathol, Teaching Hosp, Ado Ekiti, Ekiti State - Nigeria
[5] Kuwait Univ, Fac Med, Dept Pediat, Jabriya - Kuwait
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | APPLICATION OF CLINICAL GENETICS; v. 13, p. 107-114, 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Purpose: To determine the various haptoglobin genotypes and their influence on the clinico-laboratory manifestations among young Nigerian sickle cell anemia (SCA) patients. Patients and Methods: A total of 101 SCA patients and 64 controls were studied. SCA was diagnosed by polymerase chain reaction (PCR). Haptoglobin genotype was determined by PCR followed by agarose gel electrophoresis. The patients' laboratory and clinical parameters were differentiated by haptoglobin genotypes. Results: The Hp1 and Hp2 alleles frequencies were 0.62 and 0.38 in the patients and 0.73 and 0.27 in the controls, respectively, and these did not differ significantly (p>0.05). The haptoglobin genotype distribution among the patients and controls were Hp1-1, 43 (42.6%); Hp2-1, 40 (39.6%); Hp2-2, 18 (17.8%) and Hp1-1, 35 (54.7%); Hp2-1, 24 (37.5%); Hp2-2, 5 (7.8%), respectively, with no difference between the two groups (P>0.05). No significant difference was found in the clinical events and laboratory parameters of the patients when partitioned according to the various haptoglobin genotypes (P> 0.05). Conclusion: This study found that haptoglobin gene polymorphism does not have a significant influence on the clinico-laboratory manifestations among SCA patients. (AU) | |
| FAPESP's process: | 14/00984-3 - Red blood cell disorders: pathophysiology and new therapeutic approaches |
| Grantee: | Fernando Ferreira Costa |
| Support Opportunities: | Research Projects - Thematic Grants |