Peptide-metal complexes: obtention and role in increasing bioavailability and decreasing the pro-oxidant effect of minerals

Author(s)

Caetano-Silva, Maria Elisa ^[1] ; Netto, Flavia Maria ^[2] ; Bertoldo-Pacheco, Maria Teresa ^[1] ; Alegria, Amparo ^[3] ; Cilla, Antonio ^[3]

Affiliation

^[1] Inst Food Technol ITAL, Ctr Food Sci & Qual, Ave Brasil 2880, BR-13070178 Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, Fac Food Engn, Campinas, SP - Brazil

^[3] Univ Valencia, Fac Pharm, Nutr & Food Sci Area, Avda Vicente Andres Estelles S-N, Valencia - Spain

• Document type: Review article
• Source: CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION; v. 61, n. 9 MAY 2020.
• Web of Science Citations: 7

Abstract

Bioactive peptides derived from food protein sources have been widely studied in the last years, and scientific researchers have been proving their role in human health, beyond their nutritional value. Several bioactivities have been attributed to these peptides, such as immunomodulatory, antimicrobial, antioxidant, antihypertensive, and opioid. Among them, metal-binding capacity has gained prominence. Mineral chelating peptides have shown potential to be applied in food products so as to decrease mineral deficiencies since peptide-metal complexes could enhance their bioavailability. Furthermore, many studies have been investigating their potential to decrease the Fe pro-oxidant effect by forming a stable structure with the metal and avoiding its interaction with other food constituents. These complexes can be formed during gastrointestinal digestion or can be synthesized prior to intake, with the aim to protect the mineral through the gastrointestinal tract. This review addresses: (i) the amino acid residues for metal-binding peptides and their main protein sources, (ii) peptide-metal complexation prior to or during gastrointestinal digestion, (iii) the function of metal (especially Fe, Ca, and Zn)-binding peptides on the metal bioavailability and (iv) their reactivity and possible pro-oxidant and side effects. (AU)

• FAPESP's process: 15/02254-5 - Iron-whey peptide chelate: evaluation of iron bioavailability in a Caco-2 cell culture model
• Grantee: Maria Elisa Caetano Silva Abreu
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 13/10356-7 - Iron-whey peptide chelate: preparation, characterization and evaluation of pro-oxidant effect of iron and its bioavailability in a Caco-2 cell culture model
• Grantee: Maria Elisa Caetano Silva Abreu
• Support Opportunities: Scholarships in Brazil - Doctorate