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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The World of Cyclic Dinucleotides in Bacterial Behavior

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Author(s):
Aline Dias da, Purificacao [1] ; Nathalia Marins de, Azevedo [1] ; Gabriel Guarany de, Araujo [1] ; Robson Francisco de, Souza [1] ; Rodrigues, Guzzo Cristiane [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, BR-01000000 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: Molecules; v. 25, n. 10 MAY 2020.
Web of Science Citations: 0
Abstract

The regulation of multiple bacterial phenotypes was found to depend on different cyclic dinucleotides (CDNs) that constitute intracellular signaling second messenger systems. Most notably, c-di-GMP, along with proteins related to its synthesis, sensing, and degradation, was identified as playing a central role in the switching from biofilm to planktonic modes of growth. Recently, this research topic has been under expansion, with the discoveries of new CDNs, novel classes of CDN receptors, and the numerous functions regulated by these molecules. In this review, we comprehensively describe the three main bacterial enzymes involved in the synthesis of c-di-GMP, c-di-AMP, and cGAMP focusing on description of their three-dimensional structures and their structural similarities with other protein families, as well as the essential residues for catalysis. The diversity of CDN receptors is described in detail along with the residues important for the interaction with the ligand. Interestingly, genomic data strongly suggest that there is a tendency for bacterial cells to use both c-di-AMP and c-di-GMP signaling networks simultaneously, raising the question of whether there is crosstalk between different signaling systems. In summary, the large amount of sequence and structural data available allows a broad view of the complexity and the importance of these CDNs in the regulation of different bacterial behaviors. Nevertheless, how cells coordinate the different CDN signaling networks to ensure adaptation to changing environmental conditions is still open for much further exploration. (AU)

FAPESP's process: 18/21076-9 - Structure of the Xanthomonas citri type IV pilus secretin
Grantee:Gabriel Guarany de Araujo
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/08414-7 - Study of type II secretion system and the molecular bases involved c-di-GMP signaling on Leptospira interrogans serovar Copenhageni
Grantee:Cristiane Rodrigues Guzzo Carvalho
Support type: Regular Research Grants
FAPESP's process: 17/10611-8 - Study of c-di-GMP signalling mechanism in Leptospira interrogans serovar Copenhageni by LIC_11129
Grantee:Aline Dias da Purificação
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/08996-1 - Cloning and optmization of the expression conditions of LIC_11299 to LIC_11302 genic cluster
Grantee:Nathalia Marins de Azevedo
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 19/00195-2 - Understanding the c-di-GMP signaling networks and the Type II secretion system present into the human pathogen Leptospira interrogans Copenhageni
Grantee:Cristiane Rodrigues Guzzo Carvalho
Support type: Regular Research Grants