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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Impairment of nociceptive responses after neonatal anoxia correlates with somatosensory thalamic damage: A study in rats

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Author(s):
Kumar, Amrita Jha [1] ; Martins, Daniel Oliveira [2] ; Arruda, Bruna Petrucelli [1] ; Lee, Vitor Yonamine [1] ; Chacur, Marucia [1] ; Nogueira, Maria Ines [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Neurosci Lab, Av Prof Lineu Prestes 2415, BR-05508900 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Lab Funct Neuroanat Pain, Av Prof Lineu Prestes 2415, BR-05508900 Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Behavioural Brain Research; v. 390, JUL 15 2020.
Web of Science Citations: 0
Abstract

Chronic neuropathic pain resulting from damage to the central or peripheral nervous system is a prevalent and debilitating condition affecting 7-18% of the population. Symptoms include spontaneous pain, dysesthesia, paresthesia, allodynia and hyperalgesia. The reported sensory symptoms are comorbid with behavioral disabilities such as insomnia and depression. Neonatal anoxia, a worldwide clinical problem in both neonatal and pediatric care, causes long-term deficits similar to those mentioned. The effect of neonatal anoxia on the maturation of nociceptive pathways has been sparsely explored. To address this question and to determine whether the effects differ depending on sex, a neonatal anoxia model was used in which Wistar rat pups approximately 30 h old and of both sexes were placed in a chamber with 100% nitrogen flow at 3.5 L/min for 25 min at 36 degrees C +/- 1 degrees C. After recovery, the animals (n = 16 in each group (anoxia and control; males and females)) were returned to their mothers. The control animals were subjected to the same conditions, but no gas exchange was performed. At postnatal day (PND) 18 and PND43, the animals were subjected to pain testing by stimulation of the hind paws with von Frey monofilaments. The results revealed a significant reduction (approximately 50%) in the pain threshold in the animals exposed to anoxia in comparison with their respective controls. The pain threshold increased between PND18 and PND43. A sex-based difference was observed in the male control group at PND18. Histological analysis revealed decreased cell numbers in the ventral posterolateral thalamic nucleus (VPL), with sex differences. These results demonstrate the long-lasting negative impact of neonatal anoxia and indicate the relevance of performing suitable approaches taking in consideration the possible sex differences. (AU)

FAPESP's process: 15/18415-8 - Gender differences in ontogenetic development, behavior and energy metabolism in rats subjected to neonatal anoxia: focus on the hippocampus, hypothalamus, leptin and glia cels
Grantee:Maria Inês Nogueira
Support Opportunities: Regular Research Grants
FAPESP's process: 14/22313-3 - Influence of the absence of maternal melatonin during pregnancy and lactation on neurogenesis and on somatic and sensorimotor development of the offspring.
Grantee:Lívia Clemente Motta Teixeira
Support Opportunities: Scholarships in Brazil - Doctorate