| Full text | |
| Author(s): Show less - |
Kong, Xiang-Zhen
[1]
;
Boedhoe, Premika S. W.
[2, 3]
;
Abe, Yoshinari
[4]
;
Alonso, Pino
[5, 6, 7]
;
Ameis, Stephanie H.
[8, 9]
;
Arnold, Paul D.
[10, 11]
;
Assogna, Francesca
[12]
;
Baker, Justin T.
[13]
;
Batistuzzo, Marcelo C.
[14]
;
Benedetti, Francesco
[15]
;
Beucke, Jan C.
[16]
;
Bollettini, Irene
[15]
;
Bose, Anushree
[17]
;
Brem, Silvia
[18, 19, 20]
;
Brennan, Brian P.
[13]
;
Buitelaar, Jan
[21]
;
Calvo, Rosa
[22, 23, 24]
;
Cheng, Yuqi
[25]
;
Cho, Kang Ik K.
[26]
;
Dallaspezia, Sara
[15]
;
Denys, Damiaan
[27, 28]
;
Ely, Benjamin A.
[29]
;
Feusner, Jamie
[30]
;
Fitzgerald, Kate D.
[31]
;
Fouche, Jean-Paul
[32, 33]
;
Fridgeirsson, Egill A.
[27]
;
Glahn, David C.
[34, 35]
;
Gruner, Patricia
[34]
;
Gursel, Deniz A.
[36, 37]
;
Hauser, Tobias U.
[18, 19, 38, 39]
;
Hirano, Yoshiyuki
[40]
;
Hoexter, Marcelo Q.
[14]
;
Hu, Hao
[41]
;
Huyser, Chaim
[42, 43]
;
James, Anthony
[44]
;
Jaspers-Fayer, Fern
[45]
;
Kathmann, Norbert
[16]
;
Kaufmann, Christian
[16]
;
Koch, Kathrin
[36, 37]
;
Kuno, Masaru
[40]
;
Kvale, Gerd
[46, 47]
;
Kwon, Jun Soo
[48, 49]
;
Lazaro, Luisa
[22, 23, 24, 50]
;
Liu, Yanni
[31]
;
Lochner, Christine
[51]
;
Marques, Paulo
[52, 53, 54]
;
Marsh, Rachel
[55, 56]
;
Martinez-Zalacain, Ignacio
[5, 7]
;
Mataix-Cols, David
[57]
;
Medland, Sarah E.
[58]
;
Menchon, Jose M.
[5, 6, 7]
;
Minuzzi, Luciano
[59]
;
Moreira, Pedro S.
[52, 53, 54]
;
Morer, Astrid
[22, 23, 24, 50]
;
Morgado, Pedro
[52, 53, 54]
;
Nakagawa, Akiko
[40]
;
Nakamae, Takashi
[4]
;
Nakao, Tomohiro
[60]
;
Narayanaswamy, Janardhanan C.
[17]
;
Nurmi, Erika L.
[30]
;
O'Neill, Joseph
[30]
;
Pariente, Jose C.
[61]
;
Perriello, Chris
[13, 62]
;
Piacentini, John
[30]
;
Piras, Fabrizio
[12]
;
Piras, Federica
[12]
;
Pittenger, Christopher
[34]
;
Reddy, Y. C. Janardhan
;
Rus-Oswald, Oana Georgiana
[63]
;
Sakai, Yuki
[4, 64]
;
Sato, Joao R.
[65]
;
Schmaal, Lianne
[66, 67]
;
Simpson, H. Blair
[55, 68]
;
Soreni, Noam
[69]
;
Soriano-Mas, Carles
[22, 70, 5]
;
Spalletta, Gianfranco
[12, 71]
;
Stern, Emily R.
[72, 73]
;
Stevens, Michael C.
[74, 75]
;
Stewart, S. Evelyn
[76, 77]
;
Szeszko, Philip R.
[78, 79]
;
Tolin, David F.
[74, 80]
;
Tsuchiyagaito, Aki
[81, 40]
;
van Rooij, Daan
[21]
;
van Wingen, Guido A.
[27]
;
Venkatasubramanian, Ganesan
[17]
;
Wang, Zhen
[82, 83]
;
Yun, Je-Yeon
[84, 85]
;
Thompson, Paul M.
[86]
;
Stein, Dan J.
[87]
;
van den Heuvel, Odile A.
[2, 3]
;
Francks, Clyde
[88, 1]
;
Grp, ENIGMA OCD Working
Total Authors: 92
|
| Affiliation: Show less - | [1] Max Planck Inst Psycholinguist, Language & Genet Dept, Nijmegen - Netherlands
[2] Vrije Univ Amsterdam, Amsterdam Univ Med Ctr, Amsterdam Neurosci, Dept Psychiat, Amsterdam - Netherlands
[3] Vrije Univ Amsterdam, Amsterdam Univ Med Ctr, Amsterdam Neurosci, Dept Anat & Neurosci, Amsterdam - Netherlands
[4] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Psychiat, Kyoto - Japan
[5] Bellvitge Univ Hosp, Bellvitge Biomed Res Inst, Inst Invest Biomed Bellvitge, Dept Psychiat, Lhospitalet De Llobregat - Spain
[6] Univ Barcelona, Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona - Spain
[7] Univ Barcelona, Dept Clin Sci, Barcelona - Spain
[8] Univ Toronto, Margaret & Wallace McCain Ctr Child Youth & Famil, Campbell Family Mental Hlth Res Inst, Ctr Addict & Mental Hlth, Dept Psychiat, Fac Med, Toronto, ON - Canada
[9] Hosp Sick Children, Ctr Brain & Mental Hlth, Toronto, ON - Canada
[10] Univ Calgary, Hotchkiss Brain Inst, Mathison Ctr Mental Hlth Res & Educ, Calgary, AB - Canada
[11] Univ Calgary, Cumming Sch Med, Dept Psychiat, Calgary, AB - Canada
[12] Santa Lucia Fdn, Ist Ricovero & Cura Carattere Sci, Dept Clin & Behav Neurol, Lab Neuropsychiat, Rome - Italy
[13] Harvard Med Sch, McLean Hosp, Belmont, MA - USA
[14] Univ Sao Paulo, Fac Med, IPQ HCFMUSP, Dept & Inst Psiquiatria, Hosp Clin, Sao Paulo - Brazil
[15] Sci Inst Osped San Raffaele, Div Neurosci, Psychiat & Clin Psychobiol, Milan - Italy
[16] Humboldt Univ, Dept Psychol, Berlin - Germany
[17] Natl Inst Mental Hlth & Neurosci, Dept Psychiat, Obsess Compuls Disorder Clin, Bangalore, Karnataka - India
[18] Univ Zurich, Hosp Psychiat, Dept Neuroradiol, Zurich - Switzerland
[19] Univ Zurich, Hosp Psychiat, Dept Child & Adolescent Psychiat & Psychotherapy, Zurich - Switzerland
[20] Univ Zurich, Neurosci Ctr Zurich, Zurich - Switzerland
[21] Radboud Univ Nijmegen, Dept Cognit Neurosci, Nijmegen - Netherlands
[22] Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid - Spain
[23] Hosp Clin Univ, Inst Neurosci, Dept Child & Adolescent Psychiat & Psychol, Barcelona - Spain
[24] Univ Barcelona, Dept Med, Barcelona - Spain
[25] Kunming Med Univ, Affiliated Hosp 1, Dept Psychiat, Kunming, Yunnan - Peoples R China
[26] Seoul Natl Univ, Med Res Ctr, Inst Human Behav Med, Seoul - South Korea
[27] Amsterdam Neurosci, Dept Psychiat, Amsterdam - Netherlands
[28] Royal Netherlands Acad Arts & Sci, Netherlands Inst Neurosci, Amsterdam - Netherlands
[29] Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, Dept Neurosci, New York, NY 10029 - USA
[30] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 - USA
[31] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 - USA
[32] Univ Cape Town, Dept Psychiat, Cape Town - South Africa
[33] Univ Stellenbosch, Dept Psychiat, Cape Town - South Africa
[34] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT - USA
[35] Olin Neuropsychiat Res Ctr, Hartford, CT - USA
[36] Tech Univ Munich, Dept Neuroradiol, Munich - Germany
[37] Tech Univ Munich, Klinikum Rechts Isar, TUM Neuroimaging Ctr TUM NIC, Munich - Germany
[38] UCL, Max Planck UCL Ctr Computat Psychiat & Ageing Res, London - England
[39] UCL, Wellcome Ctr Human Neuroimaging, London - England
[40] Chiba Univ, Res Ctr Child Mental Dev, Chiba - Japan
[41] Shanghai Jiao Tong Univ, Sch Med, Shanghai - Peoples R China
[42] Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Child & Adolescent Psychiat, Amsterdam - Netherlands
[43] Acad Ctr Child & Adolescent Psychiat, De Bascule, Amsterdam - Netherlands
[44] Univ Oxford, Dept Psychiat, Oxford - England
[45] Univ British Columbia, Vancouver, BC - Canada
[46] Haukeland Hosp, OCD Team, Bergen - Norway
[47] Univ Bergen, Dept Clin Psychol, Bergen - Norway
[48] Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul - South Korea
[49] Seoul Natl Univ, Coll Nat Sci, Dept Brain & Cognit Sci, Seoul - South Korea
[50] Univ Autonoma Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona - Spain
[51] Univ Stellenbosch, SU UCT MRC Unit Anxiety & Stress Disorders, Cape Town - South Africa
[52] Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, Braga - Portugal
[53] Clin Acad Ctr Braga, Braga - Portugal
[54] PT Govt Associate Lab, Life & Hlth Sci Res Inst ICVS 3Bs, Braga - Portugal
[55] Columbia Univ, Irving Med Ctr, New York, NY - USA
[56] Columbia Univ, New York State Psychiat Inst, Div Child & Adolescent Psychiat, New York, NY - USA
[57] Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm - Sweden
[58] QIMR Berghofer Med Res Inst, Psychiat Genet, Brisbane, Qld - Australia
[59] St Josephs Healthcare, Mood Disorders Clin, Hamilton, ON - Canada
[60] Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiat, Fukuoka - Japan
[61] Univ Autonoma Barcelona, Magnet Resonance Image Core Facil, Barcelona - Spain
[62] Univ Illinois, Champaign, IL - USA
[63] Univ Zurich, Univ Hosp Zurich, Zurich - Switzerland
[64] ATR Brain Informat Commun Res Lab Grp, Kyoto - Japan
[65] Univ Fed ABC, Ctr Math Comp & Cognit, Santo Andre, SP - Brazil
[66] Natl Ctr Excellence Youth Mental Hlth, Orygen, Parkville, Vic - Australia
[67] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic - Australia
[68] New York State Psychiat Inst & Hosp, Ctr OCD & Related Disorders, New York, NY 10032 - USA
[69] St Josephs Healthcare, Pediat OCD Consultat Serv, Anxiety Treatment & Res Ctr, Hamilton, ON - Canada
[70] Univ Autonoma Barcelona, Dept Psychobiol & Methodol Hlth Sci, Barcelona - Spain
[71] Baylor Coll Med, Dept Psychiat & Behav Sci, Beth K & Stuart C Yudofsky Div Neuropsychiat, Houston, TX 77030 - USA
[72] NYU, Sch Med, Dept Psychiat, New York, NY - USA
[73] Nathan S Kline Inst Psychiat Res, Orangeburg, NY - USA
[74] Yale Univ, Sch Med, New Haven, CT - USA
[75] Olin Neuropsychiat Res Ctr, Clin Neurosci & Dev Lab, Hartford, CT - USA
[76] Dept Psychiat, Vancouver, BC - Canada
[77] British Columbia Childrens Hosp, Prov Obsess Compuls Disorder Program, Vancouver, BC - Canada
[78] Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, New York, NY 10029 - USA
[79] James J Peters VA Med Ctr, Bronx, NY - USA
[80] Hartford Hosp, Inst Living, Hartford, CT 06115 - USA
[81] Laureate Inst Brain Res, Tulsa, OK - USA
[82] Shanghai Mental Hlth Ctr, Shanghai - Peoples R China
[83] Shanghai Key Lab Psychot Disorders, Shanghai - Peoples R China
[84] Seoul Natl Univ, Seoul - South Korea
[85] Seoul Natl Univ, Coll Med, Yeongeon Student Support Ctr, Seoul - South Korea
[86] Univ Southern Calif, Keck Sch Med, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Marina Del Rey, CA - USA
[87] Univ Cape Town, SU UCT MRC Unit Risk & Resilience Mental Disorder, Dept Psychiat & Mental Hlth, Cape Town - South Africa
[88] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen - Netherlands
Total Affiliations: 88
|
| Document type: | Journal article |
| Source: | BIOLOGICAL PSYCHIATRY; v. 87, n. 12, p. 1022-1034, JUN 15 2020. |
| Web of Science Citations: | 6 |
| Abstract | |
BACKGROUND: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. METHODS: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. RESULTS: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = -20.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. CONCLUSIONS: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD. (AU) | |
| FAPESP's process: | 11/21357-9 - Research on neural circuits and biological markers involved in obsessive-compulsive disorder using behavioral paradigms of fear and anxiety |
| Grantee: | Eurípedes Constantino Miguel Filho |
| Support Opportunities: | Research Projects - Thematic Grants |