Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Microdose lithium reduces cellular senescence in human astrocytes - a potential pharmacotherapy for COVID-19?

Full text
Author(s):
Viel, Tania [1] ; Chinta, Shankar [2, 3] ; Rane, Anand [2] ; Chamoli, Manish [2] ; Buck, Hudson [4, 5] ; Andersen, Julie [2]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Arts Sci & Humanities, Lab Neuropharmacol Aging, Sao Paulo, SP - Brazil
[2] Buck Inst Res Aging, Novato, CA 94945 - USA
[3] Touro Univ Calif, Vallejo, CA 94592 - USA
[4] Santa Casa Sao Paulo Sch Med Sci, Dept Physiol Sci, Sao Paulo, SP - Brazil
[5] Santa Casa Sao Paulo Sch Med Sci, Dept Physiol Sci, Sao Paulo, SP, Brazil.Viel, Tania, Univ Sao Paulo, Sch Arts Sci & Humanities, Lab Neuropharmacol Aging, Sao Paulo, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: AGING-US; v. 12, n. 11, p. 10035-10040, JUN 15 2020.
Web of Science Citations: 0
Abstract

Cell senescence is a process that causes growth arrest and the release of a senescence associated secretory phenotype (SASP), characterized by secretion of chemokines, cytokines, cell growth factors and metalloproteases, leading to a tissue condition that may precipitate cancers and neurodegenerative processes. With the recent pandemic of coronavirus, senolytic drugs are being considered as possible therapeutic tools to reduce the virulence of SARS-CoV-2. In the last few years, our research group showed that lithium carbonate at microdose levels was able to stabilize memory and change neuropathological characteristics of Alzheimer's disease (AD). In the present work, we present evidence that low-dose lithium can reduce the SASP of human iPSCs-derived astrocytes following acute treatment, suggesting that microdose lithium could protect cells from senescence and development of aging-related conditions. With the present findings, a perspective of the potential use of low-dose lithium in old patients from the ``high risk group{''} for COVID-19 (with hypertension, diabetes and chronic obstructive pulmonary disease) is presented. (AU)

FAPESP's process: 18/05288-6 - A rational approach to improve the biotechnological investigation of lithium in microdosis using induced pluripotent stem cells
Grantee:Tânia Araújo Viel
Support type: Scholarships abroad - Research
FAPESP's process: 19/03486-8 - Study of the cell survival modulation by B2 receptor for bradykinin and its impact on neuroinflamation in organotypic hippocampal culture of transgenic mice for Alzheimer's Disease
Grantee:Hudson de Sousa Buck
Support type: Regular Research Grants