| Full text | |
| Author(s): |
Carvalho, Luis Felipe C. S.
[1, 2, 3]
;
dos Santos, Laurita
[4]
;
Bonnier, Franck
[5]
;
O'Callaghan, Kate
[6]
;
O'Sullivan, Jeff
[6]
;
Flint, Stephen
[6]
;
Neto, Lazaro P. M.
[4]
;
Martin, Airton A.
[4]
;
Lyng, Fiona M.
[7, 8]
;
Byrne, Hugh J.
[3, 9]
Total Authors: 10
|
| Affiliation: | [1] Univ Taubate, Taubate, SP - Brazil
[2] Ctr Univ Braz Cubas, Mogi Das Cruzes, SP - Brazil
[3] Technol Univ Dublin, FOCAS Res Inst, Kevin St, Dublin 8 - Ireland
[4] Univ Brasil, Lab Biomed Vibrat Spect, Sao Paulo, SP - Brazil
[5] Univ Francois Rabelais Tours, Fac Pharm, EA 6295, Nanomedicaments & Nanosondes, 31 Ave Monge, F-37200 Tours - France
[6] Trinity Coll Dublin, Dublin Dent Sch & Hosp, Dublin 2 - Ireland
[7] Technol Univ Dublin, FOCAS Res Inst, Radiat & Environm Sci Ctr, Kevin St, Dublin 8 - Ireland
[8] Technol Univ Dublin, Sch Phys, Kevin St, Dublin 8 - Ireland
[9] Carvalho, Luis Felipe C. S., Ctr Univ Braz Cubas, Mogi Das Cruzes, SP, Brazil.Carvalho, Luis Felipe C. S., Technol Univ Dublin, FOCAS Res Inst, Kevin St, Dublin 8 - Ireland
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | Photodiagnosis and Photodynamic Therapy; v. 30, JUN 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
The role that tobacco consumption plays in the etiology of oral cancer carcinogenesis, and of alcohol consumption acting as a co-factor, have been well established. However, in recent years, the contribution of alcohol consumption alone to oral cancer has been proposed. In fact, a high percentage of patients who develop oral cancer have both habits (tobacco and alcohol consumption), and other small patient groups only consume alcohol or do not have any other identifiable bad habits. In the present study we demonstrate, using a combination of dynamic molecular modelling and Raman spectroscopy, that ethanol has a significant effect on oral cells in vitro, mainly interacting with the lipids of the cell membrane, changing their conformation. Thus, it is possible to conclude that ethanol can affect the cell permeability, and by consequence serve as a possible trigger in oral carcinogenesis. (AU) | |
| FAPESP's process: | 14/05978-1 - In vivo Raman spectroscopy for pathological processes of oral mucosa diagnosis |
| Grantee: | Luis Felipe das Chagas e Silva de Carvalho |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |