Interleukin-17 acts in the hypothalamus reducing food intake

Author(s):Show less -

Nogueira, Guilherme ^[1] ; Solon, Carina ^{[1, 2]} ; Carraro, Rodrigo S. ^{[1, 2]} ; Engel, Daiane F. ^{[1, 2]} ; Ramalho, Albina F. ^{[1, 2]} ; Sidarta-Oliveira, Davi ^{[1, 2]} ; Gaspar, Rodrigo S. ^{[1, 2]} ; Bombassaro, Bruna ^{[1, 2]} ; Vasques, Ana C. ^{[1, 2, 3]} ; Geloneze, Bruno ^[3] ; Vinolo, Marco A. ^[4] ; Donato Junior, Jose ^[5] ; Velloso, Licio A. ^{[1, 2]}

Affiliation

^[1] Univ Estadual Campinas, Lab Cell Signalling Obes & Comorbid Res Ctr, Campinas, SP - Brazil

^[2] Donato Junior, Jose, Univ Sao Paulo, Inst Biomed Sci, Dept Physiol \& Biophys, Sao Paulo, Brazil.Nogueira, Guilherme, Univ Estadual Campinas, Lab Cell Signalling Obes & Comorbid Res Ctr, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Lab Invest Metab & Diabet, Campinas - Brazil

^[4] Univ Estadual Campinas, Dept Genet Evolut Microbiol & Immunol, Lab Immunoinflammat, Campinas - Brazil

^[5] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil

• Document type: Journal article
• Source: BRAIN BEHAVIOR AND IMMUNITY; v. 87, p. 272-285, JUL 2020.
• Web of Science Citations: 1

Abstract

Interleukin-17 (IL-17) is expressed in the intestine in response to changes in the gut microbiome landscape and plays an important role in intestinal and systemic inflammatory diseases. There is evidence that dietary factors can also modify the expression of intestinal IL-17. Here, we hypothesized that, similar to several other gutproduced factors, IL-17 may act in the hypothalamus to modulate food intake. We confirm that food intake increases IL-17 expression in the mouse ileum and human blood. There is no expression of IL-17 in the hypothalamus; however, IL-17 receptor A is expressed in both pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP) neurons. Upon systemic injection, IL-17 promoted a rapid increase in hypothalamic POMC expression, which was followed by a late increase in the expression of AgRP. Both systemic and intracerebroventricular injections of IL-17 reduced calorie intake without affecting whole-body energy expenditure. Systemic but not intracerebroventricular injection of IL-17 increase brown adipose tissue temperature. Thus, IL-17 is a gut-produced factor that is controlled by diet and modulates food intake by acting in the hypothalamus. Our findings provide the first evidence of a cytokine that is acutely regulated by food intake and plays a role in the regulation of eating. (AU)

• FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
• Grantee: Licio Augusto Velloso
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC