Impact of combined exercise training on the development of cardiometabolic and neuroimmune complications induced by fructose consumption in hypertensive rats

Author(s)

Dias, Danielle da Silva ^{[1, 2]} ; Bernardes, Nathalia ^[1] ; Stoyell-Conti, Filipe Fernandes ^[3] ; dos Santos, Camila Paixao ^[2] ; de Araujo, Amanda Aparecida ^[2] ; Llesuy, Susana ^{[1, 4]} ; Ingoyen, Maria Claudia ^[5] ; De Angelis, Katie ^{[1, 2]}

Affiliation

^[1] Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, SP - Brazil

^[2] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Sao Paulo, SP - Brazil

^[3] Univ Miami, Dept Surg, Miami, FL - USA

^[4] Hosp Italiano Buenos Aires, Inst Univ Hosp Italiano, Buenos Aires, DF - Argentina

^[5] Univ Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: PLoS One; v. 15, n. 6 JUN 10 2020.
• Web of Science Citations: 1

Abstract

This study evaluated the impact of combined exercise training on the development of cardiovascular and neuroimmune complications induced by fructose consumption (10% in the drinking water) in hypertensive rats (SHR). After weaning, SHR were divided into 3 groups: SHR (H), SHR+fructose (HF) and SHR+fructose+combined exercise training (treadmill+ladder, 40-60% of maximum capacity) (HFTC). Metabolic, hemodynamic, autonomic, inflammatory and oxidative stress parameters were evaluated in the subgroups (n = 6 group/time) at 7, 15, 30 and 60 days of protocol. Fructose consumption (H vs. HF groups) decreased spontaneous baroreflex sensitivity and total variance of pulse interval at day 7 (7 to 60); increased IL-6 and TNF alpha in the heart (at day 15, 30 and 60) and NADPH oxidase activity and cardiac lipoperoxidation (LPO) (day 60); increased white adipose tissue weight, reduced insulin sensitivity and increased triglycerides (day 60); induced an additional increase in mean arterial pressure (MAP) (days 30 and 60). Combined exercise training prevented such dysfunctions and sustained increased cardiac IL-10 (day 7) and glutathione redox balance (GSH/GSSG) for the entire protocol. In conclusion, combined exercise training performed simultaneously with exacerbated fructose consumption prevented early cardiovascular autonomic dysfunction, probably trigging positive changes in inflammation and oxidative stress, resulting in a better cardiometabolic profile in rats genetically predisposed to hypertension. (AU)

• FAPESP's process: 15/11223-6 - Time course of neuroimmune changes induced by chronic fructose consumption in normotensive and hypertensive rats: role of aerobic exercise training
• Grantee: Kátia de Angelis Lobo D Avila
• Support Opportunities: Regular Research Grants