Evaluation of platelet activating factor receptor function in oral squamous carcin...
| Full text | |
| Author(s): Show less - |
Archanjo, Anderson Barros
[1]
;
Evangelista Monteiro de Assis, Aricia Leone
[1]
;
de Oliveira, Mayara Mota
[1]
;
Mendes, Suzanny Oliveira
[1]
;
Borcoi, Aline Ribeiro
[1]
;
Maia, Lucas de Lima
[1]
;
de Souza, Rafael Pereira
[2]
;
de Cicco, Rafael
[2]
;
Saito, Kelly Cristina
[3]
;
Kimura, Edna Teruko
[3]
;
de Carvalho, Marcos Brasilino
[4]
;
Nunes, Fabio Daumas
[5]
;
Tajara, Eloiza H.
[6]
;
dos Santos, Marcelo
[7]
;
Nogueira, Breno Valentim
[1]
;
Trivilin, Leonardo Oliveira
[8]
;
Gomes Pinheiro, Christiano Jorge
[8]
;
Alvares-da-Silva, Adriana Madeira
[1]
Total Authors: 18
|
| Affiliation: | [1] Univ Fed Espirito Santo, Postgrad Program Biotechnol RENORBIO, Av Marechal Campos 1468, BR-29040090 Vitoria, ES - Brazil
[2] Canc Inst Arnaldo Vieira de Carvalho, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil
[4] Heliopolis Hosp, Mol Biol Lab, Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Dent, Sao Paulo - Brazil
[6] Med Sch Sao Jose do Rio Preto, Sao Jose Do Rio Preto - Brazil
[7] Univ Fed Rio Grande do Norte, Multicampi Sch Med Sci Rio Grande do Norte, Caico - Brazil
[8] Univ Fed Espirito Santo, Ctr Agr Sci & Engn, Alegre - Brazil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 10, n. 1 JUN 25 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Oral cancer squamous cell carcinoma (OCSCC) mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. Tobacco smoke contains hundreds of known toxic and carcinogenic molecules, and a few studies have sought to verify the relationship of such trace elements as risk or prognostic factors for head and neck cancer. We obtained 78 samples of tumor tissues from patients with OCSCC, and performed a qualitative elemental characterization using the micro X-Ray Fluorescence technique based on synchrotron radiation. We found the presence of magnesium, phosphorus, sulfur, chlorine, potassium, calcium, chromium, manganese, iron, zinc, cobalt, nickel, copper, arsenic and bromine in OCSCC samples. Magnesium, chlorine, chromium, manganese, nickel, arsenic and bromine are associated with smoking. We observed a significant association between relapse and chlorine and chromium. The presence of chlorine in the samples was an independent protective factor against relapse (OR=0.105, CI=0.01-0.63) and for best disease-free survival (HR=0.194, CI=0.04-0.87). Reporting for the first time in oral cancer, these results suggest a key relationship between smoking and the presence of certain elements. In addition, chlorine proved to be important in the context of patient prognosis and survival. (AU) | |
| FAPESP's process: | 04/12054-9 - Markers of aggressive behavior in head and neck tumors |
| Grantee: | Eloiza Helena Tajara da Silva |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 10/51168-0 - Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas |
| Grantee: | Eloiza Helena Tajara da Silva |
| Support type: | Research Projects - Thematic Grants |