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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Functional changes induced by caloric restriction in cardiac and skeletal muscle mitochondria

Full text
Author(s):
Serna, Julian David C. [1] ; Caldeira da Silva, Camille C. [1] ; Kowaltowski, Alicia J. [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Dept Bioquim, Bist Quim, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Bioenergetics and Biomembranes; v. 52, n. 4, p. 269-277, AUG 2020.
Web of Science Citations: 0
Abstract

Caloric restriction (CR) is widely known to increase life span and resistance to different types of injuries in several organisms. We have previously shown that mitochondria from livers or brains of CR animals exhibit higher calcium uptake rates and lower sensitivity to calcium-induced mitochondrial permeability transition (mPT), an event related to the resilient phenotype exhibited by these organs. Given the importance of calcium in metabolic control and cell homeostasis, we aimed here to uncover possible changes in mitochondrial calcium handling, redox balance and bioenergetics in cardiac and skeletal muscle mitochondria in response to six months of CR. Unexpectedly, we found that CR does not alter the susceptibility to mPT in muscle (cardiac or skeletal), nor calcium uptake rates. Despite the lack in changes in calcium transport properties, CR consistently decreased respiration in the presence of ATP synthesis in heart and soleus muscle. In heart, such changes were accompanied by a decrease in respiration in the absence of ATP synthesis, lower maximal respiratory rates and a reduced rate of hydrogen peroxide release. Hydrogen peroxide release was unaltered by CR in skeletal muscle. No changes were observed in inner membrane potentials and respiratory control ratios. Together, these results highlight the tissue-specific bioenergetic and ion transport effects induced by CR, demonstrating that resilience against calcium-induced mPT is not present in all tissues. (AU)

FAPESP's process: 16/18633-8 - Expansion of satellite cell pools in adult skeletal muscle: role of bioenergetics and mitochondrial alterations induced by aerobic exercise
Grantee:Phablo Sávio Abreu Teixeira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC