Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes

Author(s):Show less -

Frizzell, H. ^{[1, 2]} ; Fonseca, R. ^[1] ; Christo, S. N. ^[1] ; Evrard, M. ^[1] ; Cruz-Gomez, S. ^[1] ; Zanluqui, N. G. ^{[3, 1]} ; von Scheidt, B. ^[1] ; Freestone, D. ^[1] ; Park, S. L. ^[1] ; McWilliam, H. E. G. ^{[1, 4]} ; Villadangos, J. A. ^{[1, 4]} ; Carbone, F. R. ^[1] ; Mackay, L. K. ^[1]

Affiliation

^[1] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic - Australia

^[2] Univ Washington, Dept Bioengn, Seattle, WA 98195 - USA

^[3] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, SP - Brazil

^[4] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Dept Biochem & Mol Biol, Melbourne, Vic - Australia

• Document type: Journal article
• Source: SCIENCE IMMUNOLOGY; v. 5, n. 46 APR 2020.
• Web of Science Citations: 1

Abstract

Tissue-resident memory T (T-RM) cells exist throughout the body, where they are poised to mediate local immune responses. Although studies have defined a common mechanism of residency independent of location, there is likely to be a level of specialization that adapts T-RM cells to their given tissue of lodgment. It has been shown that T-RM cells in the skin rely on the uptake of exogenous fatty acids for their survival and up-regulate fatty acid-binding protein 4 (FABP4) and FABP5 as part of their transcriptional program. However, FABPs exist as a larger family of isoforms, with different members selected in a tissue-specific fashion that is optimized for local fatty acid availability. Here, we show that although T-RM cells in a range of tissue widely express FABPs, they are not restricted to FABP4 and FABP5. Instead, T-RM cells show varying patterns of isoform usage that are determined by tissue-derived factors. These patterns are malleable because T-RM cells relocated to different organs modify their FABP expression in line with their new location. As a consequence, these results argue for tissue-specific overlays to the T-RM cell residency program, including FABP expression that is tailored to the particular tissue of T-RM cell lodgment. (AU)

• FAPESP's process: 19/12431-2 - CD8 regulatory T cells: Friend or foe in routes of infection
• Grantee: Nagela Ghabdan Zanluqui
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate