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BDNF involvement in the function of lymphocytes of sedentary obese and trained: relationship with cognitive

Grant number: 16/16712-8
Support Opportunities:Regular Research Grants
Duration: December 01, 2016 - November 30, 2018
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Fábio Santos de Lira
Grantee:Fábio Santos de Lira
Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil


The brain-derived neurotrophic factor (BDNF) is known to be related to neuroprotection and neurogenesis, as well as being involved in cognition, mood, cardiovascular function and energy metabolism. BDNF plays "cross-talk" between the nervous system and immune system, which BDNF signaling pathway in lymphocytes could reflect at least in part, the same signal in the cortex, and this relationship isoform dependent. The pro-BDNF be involved in apoptotic processes, while mature-BDNF could be related to the survival and plasticity to bind to its high affinity receptor, tropomyosin related kinase B (TrkB). genetic factors, sedentary lifestyle and chronic stress have an impact on the signaling of BDNF, which may contribute to the decline of cognitive function. Recently, much has been speculated on cognition in obesity, with hypertrophy of the visceral adipose tissue (VAT) as a link of this relationship, and this may be related to reduced concentrations of BDNF, especially in sedentary obese individuals. However, recent studies have shown that acute exercise, particularly high-intensity flashing may promote increased concentrations of BDNF. However, little is known about the effects that this type of exercise can have long-term. Forward this issue, knowledge about the effects of intermittent high intensity training is incipient (HIIT - high intensity intermittent training) on cognitive function of young obese adults accompanying the anthropometric changes and imunometabólicas. To answer this question, obese adult men will be recruited and divided into two groups: HIIT (10 shots 1 minute to 100% vVO2pico for 1 minute passive rest) or control group. They will be assessed before and after 6 weeks of training on the following parameters: cognitive (memory, attention and executive function), morphological (X-ray absorptiometry dual energy and octopolar bioelectrical impedance), biochemical (cytokines anti and pro-inflammatory, lipid profile, blood glucose and insulin) and molecular (lymphocyte culture with / without BDNF stimulation, quantification of proteins and gene expression). At the end of this research, it is expected that HIIT result in higher concentrations of BDNF, this response being a consequence of changes in many of the above parameters as well as allowing an improvement in cognitive function. (AU)

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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROSSI, FABRICIO EDUARDO; DE FREITAS, MARCELO CONRADO; ZANCHI, NELO EIDY; LIRA, FABIO SANTOS; CHOLEWA, JASON M.. The Role of Inflammation and Immune Cells in Blood Flow Restriction Training Adaptation: A Review. FRONTIERS IN PHYSIOLOGY, v. 9, . (15/23910-8, 16/16712-8)
LIRA, F. S.; ANTUNES, B. M.; FIGUEIREDO, C.; CAMPOS, E. Z.; PANISSA, V. L. G.; ST-PIERRE, D. H.; LAVOIE, J. -M.; MAGRI-TOMAZ, L.. Impact of 5-week high-intensity interval training on indices of cardio metabolic health in men. DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS, v. 13, n. 2, p. 1359-1364, . (16/16712-8, 15/23127-1, 15/11302-3)
CABRAL-SANTOS, CAROLINA; DE LIMA JUNIOR, EDSON ALVES; DA CRUZ FERNANDES, ISABELA MAIA; PINTO, RAFAEL ZAMBELLI; ROSA-NETO, JOSE CESAR; BISHOP, NICOLETTE CHARLLOTE; LIRA, FABIO SANTOS. Interleukin-10 responses from acute exercise in healthy subjects: A systematic review. Journal of Cellular Physiology, v. 234, n. 7, p. 9956-9965, . (15/26148-0, 15/17068-2, 16/16712-8)
INOUE, DANIELA SAYURI; MONTEIRO, PAULA ALVES; GEROSA-NETO, JOSE; SANTANA, PRISCILLA RODRIGUES; PERES, FERNANDO PIERIN; EDWARDS, KATE M.; LIRA, FABIO SANTOS. Acute increases in brain-derived neurotrophic factor following high or moderate-intensity exercise is accompanied with better cognition performance in obese adults. SCIENTIFIC REPORTS, v. 10, n. 1, . (16/16712-8, 15/22402-9, 17/03947-0)
GEROSA-NETO, JOSE; MONTEIRO, PAULA ALVES; INOUE, DANIELA SAYURI; ANTUNES, BARBARA MOURA; BATATINHA, HELENA; DORNELES, GILSON PIRES; PERES, ALESSANDRA; ROSA-NETO, JOSE CESAR; LIRA, FABIO SANTOS. High- and moderate-intensity training modify LPS-induced ex-vivo interleukin-10 production in obese men in response to an acute exercise bout. CYTOKINE, v. 136, . (16/16712-8, 15/22402-9)
MARQUES, LEANDRO R.; DINIZ, TIEGO A.; ANTUNES, BARBARA M.; ROSSI, FABRICIO E.; CAPERUTO, ERICO C.; LIRA, FABIO S.; GONCALVES, DANIELA C.. Reverse Cholesterol Transport: Molecular Mechanisms and the Non-medical Approach to Enhance HDL Cholesterol. FRONTIERS IN PHYSIOLOGY, v. 9, . (16/16712-8)
CALDEIRA, RENAN SANTOS; GONCALVES PANISSA, VALERIA LEME; INOUE, DANIELA SAYURI; CAMPOS, EDUARDO ZAPATERRA; MONTEIRO, PAULA ALVES; GIGLIO, BRUNA DE MELO; PIMENTEL, GUSTAVO DUARTE; HOFMANN, PETER; LIRA, FABIO SANTOS. Impact to short-term high intensity intermittent training on different storages of body fat, leptin and soluble leptin receptor levels in physically active non-obese men: A pilot investigation. CLINICAL NUTRITION ESPEN, v. 28, p. 186-192, . (15/12979-7, 15/11302-3, 17/07304-6, 16/16712-8)
LIRA, FABIO SANTOS; DOS SANTOS, THAISLAINE; CALDEIRA, RENAN SANTOS; INOUE, DANIELA S.; PANISSA, VALERIA L. G.; CABRAL-SANTOS, CAROLINA; CAMPOS, EDUARDO Z.; RODRIGUES, BRUNO; MONTEIRO, PAULA A.. Short-Term High- and Moderate-Intensity Training Modifies Inflammatory and Metabolic Factors in Response to Acute Exercise. FRONTIERS IN PHYSIOLOGY, v. 8, . (15/12979-7, 16/16712-8, 15/11302-3, 16/12145-1)
INOUE, DANIELA S.; ANTUNES, BARBARA M.; MAIDEEN, MOHAMMAD F. B.; LIRA, FABIO S.. Pathophysiological Features of Obesity and its Impact on Cognition: Exercise Training as a Non-Pharmacological Approach. CURRENT PHARMACEUTICAL DESIGN, v. 26, n. 9, p. 916-931, . (17/03947-0, 15/22402-9, 16/16712-8)

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