"Impact of high intensity interval exercise on cognitive function, morphological changes and systemic imunometabólicas of young people with obesity"

• Grant number: 15/22402-9
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): March 01, 2016
• Effective date (End): June 30, 2019
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Fábio Santos de Lira
• Grantee: Daniela Sayuri Inoue Yoshimura
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
• Associated scholarship(s): 17/03947-0 - Effects of heat intervention during physical exercise on BDNF response in pregnancy, BE.EP.DR

Abstract

It has been speculated about the relationship of obesity and cognitive function decline. In this context, the visceral adipose tissue (VAT) is a key component of metabolic dysregulation, and when combined with lower concentrations of brain-derived neurotrophic factors (BDNF), promoting cognitive decline. BDNF is involved in different cell functions, however it highlights its effect on the neuroregeneration process essential for maintenance of cognitive functions. Their concentrations are reduced in obese individuals and recent studies have shown that physical exercise can promote increased BDNF concentrations. However, the knowledge about the effects of high intensity and intermittent aerobic training (HIIT) is incipient on cognitive function of young obese adults concomitant anthropometric and imunometabolic changes. Therefore, obese adult who will be recruited and randomized into two groups: HIIT (10x1 minute vVO2pico 100% for 1 minute passive rest) and moderate continuous aerobic training (65% vVO2 with energy expenditure equivalent to HIIT). Imunometabolic parameters (cytokines anti and pro-inflammatory, lipid profile, blood glucose and insulin) and morphological (X-ray absorptiometry dual energy and octopolar bioelectrical impedance analysis), and cognitive function (memory, attention and executive function) that will be analyzed and compared to the end of the 6 weeks of training. It is expected that improvements in biochemical and morphological parameters reflect cognitive function.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

INOUE, DANIELA S.; ANTUNES, BARBARA M.; MAIDEEN, MOHAMMAD F. B.; LIRA, FABIO S.. Pathophysiological Features of Obesity and its Impact on Cognition: Exercise Training as a Non-Pharmacological Approach. CURRENT PHARMACEUTICAL DESIGN, v. 26, n. 9, p. 916-931, 2020. (17/03947-0, 15/22402-9, 16/16712-8)

GEROSA-NETO, JOSE; MONTEIRO, PAULA ALVES; INOUE, DANIELA SAYURI; ANTUNES, BARBARA MOURA; BATATINHA, HELENA; DORNELES, GILSON PIRES; PERES, ALESSANDRA; ROSA-NETO, JOSE CESAR; LIRA, FABIO SANTOS. High- and moderate-intensity training modify LPS-induced ex-vivo interleukin-10 production in obese men in response to an acute exercise bout. CYTOKINE, v. 136, DEC 2020. (16/16712-8, 15/22402-9)

INOUE, DANIELA SAYURI; MONTEIRO, PAULA ALVES; GEROSA-NETO, JOSE; SANTANA, PRISCILLA RODRIGUES; PERES, FERNANDO PIERIN; EDWARDS, KATE M.; LIRA, FABIO SANTOS. Acute increases in brain-derived neurotrophic factor following high or moderate-intensity exercise is accompanied with better cognition performance in obese adults. SCIENTIFIC REPORTS, v. 10, n. 1, AUG 10 2020. (16/16712-8, 15/22402-9, 17/03947-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

YOSHIMURA, Daniela Sayuri Inoue. Impact of high-intensity intermittent training on cognitive function, morphological and immunometabolic changes of adults with obesity. 2019. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências e Tecnologia. Presidente Prudente Presidente Prudente.