An efficient approach for the synthesis of new (+/-)-coixspirolactams

Nascimento, Vinicius R.; Suenaga, Melissa L. S.; Andrade, Leandro H.

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An efficient approach for the synthesis of new (+/-)-coixspirolactams

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Author(s):	Nascimento, Vinicius R. ^[1] ; Suenaga, Melissa L. S. ^[1] ; Andrade, Leandro H. ^[1] Total Authors: 3
Affiliation:	^[1] Univ Sao Paulo, Inst Chem, Sao Paulo - Brazil Total Affiliations: 1
Document type:	Journal article
Source:	ORGANIC & BIOMOLECULAR CHEMISTRY; v. 18, n. 28, p. 5458-5465, JUL 28 2020.
Web of Science Citations:	0
Abstract
Coixspirolactams, spiro{[}oxindole-gamma-lactones], are found in adlay seeds and exhibit anticancer activity. A novel synthetic methodology was developed to enable an easy access to (+/-)-coixspirolactam A and a large number of new coixspirolactams in excellent overall yields. The exquisite exploitation of formamide reactivity was essential for the construction of oxindole and lactone scaffolds. (AU)

FAPESP's process:	19/10762-1 - Development of a synthetic platform using carbamoyl radicals: application of the formamide in the synthesis of heterocyclic compounds
Grantee:	Leandro Helgueira de Andrade
Support Opportunities:	Regular Research Grants


FAPESP's process:	17/02854-8 - Synthetic applications of carbamoyl radicals via photocatalysis
Grantee:	Leandro Helgueira de Andrade
Support Opportunities:	Regular Research Grants

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