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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dysregulation of Midbrain Dopamine System and the Pathophysiology of Schizophrenia

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Author(s):
Sonnenschein, Susan F. [1] ; Gomes, Felipe V. [2] ; Grace, Anthony A. [1]
Total Authors: 3
Affiliation:
[1] Univ Pittsburgh, Dept Neuroscie Psychiat & Psychol, Pittsburgh, PA 15260 - USA
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto - Brazil
Total Affiliations: 2
Document type: Review article
Source: FRONTIERS IN PSYCHIATRY; v. 11, JUN 30 2020.
Web of Science Citations: 0
Abstract

Dysregulation of the dopamine system is central to many models of the pathophysiology of psychosis in schizophrenia. However, emerging evidence suggests that this dysregulation is driven by the disruption of upstream circuits that provide afferent control of midbrain dopamine neurons. Furthermore, stress can profoundly disrupt this regulatory circuit, particularly when it is presented at critical vulnerable prepubertal time points. This review will discuss the dopamine system and the circuits that regulate it, focusing on the hippocampus, medial prefrontal cortex, thalamic nuclei, and medial septum, and the impact of stress. A greater understanding of the regulation of the dopamine system and its disruption in schizophrenia may provide a more complete neurobiological framework to interpret clinical findings and develop novel treatments. (AU)

FAPESP's process: 18/17597-3 - The impact of stress on the dopamine system depends on the state of the critical period of neuroplasticity: implications for depression and schizophrenia and for the study of new drug targets
Grantee:Felipe Villela Gomes
Support Opportunities: Research Grants - Young Investigators Grants