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EVALUATION OF EFFECTS OF NEONATAL HYPOXIA ON SCHIZOPHRENIA DEVELOPMENT: ROLE OF ADENOSINERGIC SYSTEM

Grant number: 15/26820-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2016
Effective date (End): June 30, 2020
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal researcher:Mariana Bendlin Calzavara
Grantee:Aline Camargo Ramos
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Recently much attention has been focused on the role of neurodevelopment in schizophrenia. It is believed that the manifestation of schizophrenia, reflecting the striatal hiperdopaminérgico state, is the end result of changes that emerge from the interaction between genetic and environmental factors and related to neural development throughout life. Pharmacotherapy of schizophrenia based on the dopamine hypothesis remains unsatisfactory for the treatment of negative symptoms and cognitive deficits related to this disease. Adenosine is a homeostatic modulator that is able to affect various complex networks as dependent pathways of neurotransmitters, bioenergetics and epigenetics. In this regard, adenosine appears to be a promising candidate in the correction of functional imbalance found in schizophrenia and may influence the dopaminergic and glutamatergic systems. Evidence points to an important adenosine participation in neural development and indicate a potential involvement of this substance in the etiology of schizophrenia. Perinatal hypoxia is one of the most well-established risk factors for the development of schizophrenia, however, there are few studies that attempt to clarify the mechanisms related to the participation of hypoxia in major pathophysiological hypotheses of schizophrenia. Systems subjected to hypoxia is an increase of adenosine as an adaptive responses. Many accrues in permanent changes still not well established effects that seem to play an important role in the pathophysiology of numerous diseases, including schizophrenia. Animal and cell models can be interesting tools for the study of interventions such as perinatal hypoxia and its effects on brain function and behavioral changes that mimic the underlying schizophrenia. This project aims to study the effects of neonatal hypoxia in the development of schizophrenia by assessing the role of adenosinergic system in the modulation of dopaminergic and glutamatergic systems.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VARGA, THIAGO GARCIA; DE TOLEDO SIMOES, JUAN GUILHERME; SIENA, AMANDA; HENRIQUE, ELISANDRA; DA SILVA, REGINA CLAUDIA BARBOSA; DOS SANTOS BIONI, VINICIUS; RAMOS, ALINE CAMARGO; ROSENSTOCK, TATIANA ROSADO. Haloperidol rescues the schizophrenia-like phenotype in adulthood after rotenone administration in neonatal rats. Psychopharmacology, v. 238, n. 9, p. 2569-2585, SEP 2021. Web of Science Citations: 0.
VARGA, THIAGO GARCIA; DE TOLEDO SIMOES, JUAN GUILHERME; SIENA, AMANDA; HENRIQUE, ELISANDRA; DA SILVA, REGINA CLAUDIA BARBOSA; DOS SANTOS BIONI, VINICIUS; RAMOS, ALINE CAMARGO; ROSENSTOCK, TATIANA ROSADO. Haloperidol rescues the schizophrenia-like phenotype in adulthood after rotenone administration in neonatal rats. Psychopharmacology, JUN 2021. Web of Science Citations: 0.
RAMOS, ALINE CAMARGO; HUNGRIA, FILIPE DE MATTOS; CAMERINI, BIANCA AVANSI; SUIAMA, MAYRA AKIMI; CALZAVARA, MARIANA BENDLIN. Potential beneficial effects of caffeine administration in the neonatal period of an animal model of schizophrenia. Behavioural Brain Research, v. 391, AUG 5 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.