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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Adipogenic commitment induced by green tea polyphenols remodel adipocytes to a thermogenic phenotype

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Bolin, Anaysa Paola [1] ; Batista Sousa-Filho, Celso Pereira [2] ; Nascimento dos Santos, Gustavo Tolentino [2] ; Ferreira, Leticia Torres [2] ; Martins de Andrade, Paula Bresciani [2] ; Migliorini Figueira, Ana Carolina [3] ; Heleno Batista, Fernanda Aparecida [3] ; Otton, Rosemari [1, 2]
Total Authors: 8
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo - Brazil
[2] Cruzeiro do Sul Univ, Interdisciplinary Postgrad Programme Hlth Sci, Sao Paulo - Brazil
[3] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Biosci Natl Lab, Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 1

The potential contribution of green tea (GT) to the development of thermogenic/beige cells have been scarcely investigated. Here we investigated if the beneficial effects of GT in the induction of thermogenic/beige adipocytes results from an initial cell commitment during adipogenesis. Male C57Bl/6 mice (3 months) were divided into 3 groups: Control (chow diet), Obese (cafeteria diet), and Obese + GT. Mice received GT gavage (500 mg/kg of BW) over 12 weeks (5 days/week), after 4 weeks of diet, totalizing 16 weeks of experimentation. GT treatment increased energy expenditure (EE) in mice fed with cafeteria-diet leading to reduced BW gain, decreased adiposity, reduced inflammation, and improving insulin sensitivity. Those phenotypes were associated with enhanced expression of oxidative, thermogenic and beige genes. GT induced a futile cycle through de novo lipogenesis activating the thermogenic pathway. Induction of beige phenotype occurs autonomously in adipocytes and involves the PPAR gamma/FGF21/AMPK/UCP1 pathway. Our study identified that metabolic changes caused by GT may involve the temporal expression of PPAR gamma promoting the induction of thermogenic cells by reprogramming initial steps of adipocyte commitment. (C) 2020 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 11/19216-8 - Systematic evaluation of oxidative and inflammatory parameters in obese rats chronically supplemented with green tea extract (Camellia sinensis)
Grantee:Rosemari Otton
Support type: Regular Research Grants
FAPESP's process: 15/07024-8 - Energy expenditure evaluation and metabolic characterization of brown and subcutaneous adipose tissues in obese mice supplemented with green tea
Grantee:Gustavo Tolentino Nascimento dos Santos
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/22293-0 - Identification and validation of miRNA target genes in adipose tissue and liver of obese mice in response to treatment with green tea extract
Grantee:Rosemari Otton
Support type: Regular Research Grants
FAPESP's process: 12/20415-8 - Modulation of endoplasmic reticulum stress in adipocytes and leukocytes of mice induced to obesity and chronically treated with green tea extract (Camellia sinensis)
Grantee:Anaysa Paola Bolin
Support type: Scholarships in Brazil - Doctorate