Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial Infarction

Author(s)

Batista, Diego Fernando ^[1] ; Polegato, Bertha Furlan ^[1] ; da Silva, Renata Candido ^[1] ; Claro, Renan Turini ^[1] ; Azevedo, Paula Shmidt ^[1] ; Fernandes, Ana Angelica ^[2] ; Okoshi, Katashi ^[1] ; de Paiva, Sergio Alberto Rupp ^[1] ; Minicucci, Marcos Ferreira ^[1] ; Zornorff, Leonardo Antonio Mamede ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Botucatu, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Chem & Biochem, Inst Biosci Botucatu, Botucatu, SP - Brazil

• Document type: Journal article
• Source: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY; v. 2020, JUL 20 2020.
• Web of Science Citations: 0

Abstract

The objective of this study was to analyze the impact of different modalities and intensities of exercise training on cardiac remodeling started early after experimental myocardial infarction (MI). Male Wistar rats, weighing 200-250 g, were subjected to experimental MI. After 5 days, the animals were allocated into three experimental groups and observed for three months: S (sedentary control animals), C (animals subjected to continuous low-intensity training), and HIT (animals subjected to high-intensity interval training). Low-intensity exercise training was performed at a treadmill speed corresponding to 40% VO(2)max, which was kept unchanged throughout the entire session (i.e., continuous low-intensity training). High-intensity interval training was performed in such a way that rats run during 3 min at 60% VO(2)max, followed by 4-minute intervals at 85% VO(2)max (i.e., high-intensity interval training). After the follow-up period, we studied hypertrophy and ventricular geometry, functional alterationsin vivoandin vitro, oxidative stress, apoptosis, and cardiac energetic metabolism. Our data showed that both high-intensity interval and continuous low-intensity modalities improved cardiac energetic metabolism variables in comparison with sedentary infarcted animals. In addition, high-intensity interval training decreased cardiac oxidative stress, associated with improved diastolic function. On the other hand, the continuous low-intensity group showed impairment of cardiac function. Therefore, altogether, our data suggest that high-intensity interval training could be the best modality for early physical exercise after MI and should be better studied in this clinical scenario. (AU)

• FAPESP's process: 18/20790-0 - Role of netosis as modulator of doxorubicin-induced cardiotoxicity
• Grantee: Leonardo Antonio Mamede Zornoff
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/22051-3 - Impact of exercise intensity early after myocardial infarction in the cardiac remodeling process
• Grantee: Diego Fernando Batista
• Support Opportunities: Scholarships in Brazil - Doctorate