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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development and characterization of printablePLA/beta-TCPbioactive composites for bone tissue applications

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Author(s):
Backes, Eduardo Henrique [1] ; Pires, Lais de Nobile [2] ; Selistre-de-Araujo, Heloisa Sobreiro [3] ; Costa, Lidiane Cristina [1] ; Passador, Fabio Roberto [4] ; Pessan, Luiz Antonio [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Carlos, Grad Program Mat Sci & Engn, Rodovia Washington Luiz, Km 235, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Mat Engn Dept, Sao Carlos, SP - Brazil
[3] Univ Fed Sao Carlos, Dept Physiol Sci, Sao Carlos, SP - Brazil
[4] Univ Fed Sao Paulo, Sci & Technol Inst, Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Applied Polymer Science; v. 138, n. 5 AUG 2020.
Web of Science Citations: 0
Abstract

In this study, poly(lactic acid) (PLA) and PLA/beta-tricalcium phosphate (TCP) biocomposites were developed by melt compounding using an internal melt mixer with three different TCP contents (5, 10, and 25 wt%). A comprehensive analysis of the thermal, rheological, and mechanical properties of these biocomposites was performed. TCP presented proper distribution in the PLA/TCP biocomposites: PLA5TCP and PLA10TCP exhibited rheological behavior similar to that of neat PLA. However, PLA25TCP presented significant agglomeration and reduction in thermal stability. Addition of TCP to the biocomposites enhanced their bioactivity and biocompatibility. The bioactivity assay was conducted by immersing the samples in SBF solution for 7 and 21 days, and the SEM and XRD surface analyses of the PLA/TCP biocomposites presented evidence of carbonated hydroxyapatite formation. The biocompatibility assay was performed using the extract method until 7 days, and PLA10TCP presented improved relative cell viability compared with the control. Finally, since the materials presented suitable thermal and rheological properties, filaments for additive manufacturing (AM) were developed, and they were used to produce screw models for bone-ligament fixation. The 3D printed screws exhibited excellent printability and accuracy. Therefore, the PLA/TCP biocomposites developed can be used in further biomedical applications using AM, namely, guided bone tissue engineering. (AU)

FAPESP's process: 16/19978-9 - Development of PA6/LLDPE blend-based carbon black nanocomposites for antistatic packaging for electronic components
Grantee:Fabio Roberto Passador
Support Opportunities: Regular Research Grants
FAPESP's process: 19/11437-7 - Integrin molecular mechanisms of action during tumor progression and metastasis development: an intercellular approach
Grantee:Heloisa Sobreiro Selistre de Araújo
Support Opportunities: Regular Research Grants
FAPESP's process: 17/11366-7 - Development of bio-inspired PLA/bioglass scaffolds via 3D printed
Grantee:Eduardo Henrique Backes
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/09609-9 - Development of bioinspired scaffolds of PLA/bioactive ceramic fillers through 3D printing
Grantee:Luiz Antonio Pessan
Support Opportunities: Regular Research Grants
FAPESP's process: 11/21313-1 - Study of the reaction kinetic and the addition of the metal deactivators in the grafting of maleic anhydride onto polypropylene in the presence and absence of the nanoparticles
Grantee:Silvia Helena Prado Bettini
Support Opportunities: Regular Research Grants