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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Gastric healing effect ofp-coumaric acid isolated fromBaccharis dracunculifoliaDC on animal model

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Author(s):
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Boeing, Thaise [1, 2] ; Costa, Philipe [2] ; Venzon, Larissa [2] ; Meurer, Mariane [2] ; Bolda Mariano, Luisa Nathalia [2] ; Santos Franca, Tauani Caroline [2] ; Gouveia, Luana [2] ; de Bassi, Anny Caroline [2] ; Steimbach, Viviane [2] ; de Souza, Priscila [2] ; de Almeida, Marilia Oliveira [1] ; Arruda, Caroline [1] ; de Andrade, Sergio Faloni [2] ; Bastos, Jairo Kenupp [1] ; da Silva, Luisa Mota [2]
Total Authors: 15
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, SP - Brazil
[2] Univ Vale Itajai UNIVALI, Nucleo Invest Quim Farmaceut NIQFAR, Programa Posgrad Ciencias Farmaceut PPGCF, Itajai, SC - Brazil
Total Affiliations: 2
Document type: Journal article
Source: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY; v. 394, n. 1 AUG 2020.
Web of Science Citations: 1
Abstract

Thep-coumaric acid is a phenolic compound present in large quantities in the extract ofBaccharis dracunculifoliaDC, a Brazilian medicinal plant used to treat gastric ulcer. Given the necessity for finding new chemical components capable of accelerating gastric healing, in this study, the effects of thep-coumaric acid were evaluated in the acetic acid-induced ulcer model in rats, where histological, inflammatory, and oxidative parameters were analyzed. The healing property was also evaluated in the scratch assay on fibroblast cells (L929) and the cytotoxicity ofp-coumaric acid was assessed in both L929 and human gastric adenocarcinoma (AGS) cells by MTT assay. The treatment withp-coumaric acid (10 mg/kg, p.o.) for 7 days, twice a day, decreased by 44.6% the acetic acid-induced gastric ulcer compared with the vehicle-treated group. The vehicle control-treated group showed a larger extension of the ulcer base and an extensive damage into the mucosa and submucosa layers, which were mitigated by the treatment withp-coumaric acid. This beneficial effect was also associated with increased levels of mucin and reduced glutathione, decreased amount of lipid hydroperoxides, and increased superoxide dismutase and catalase activities without interfering with the activity of myeloperoxidase in the gastric tissue. The compound promoted the restructuring of the cell monolayer in the scratch test and did not show toxicity in the L929 cell line, while reduced the viability of the AGS, a lineage of human gastric adenocarcinoma. Thus,p-coumaric acid may be considered a natural source for the treatment of gastric ulcers, by reinforcing protective factors of gastric mucosa and by accelerating gastric healing. (AU)

FAPESP's process: 17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector
Grantee:Jairo Kenupp Bastos
Support Opportunities: Research Projects - Thematic Grants