| Full text | |
| Author(s): |
Ybarra, Luiz F.
[1, 2]
;
Szarf, Gilberto
[1]
;
Ishikawa, Walther
[1]
;
Chamie, Daniel
[3, 4]
;
Caixeta, Adriano
[1]
;
Puri, Rishi
[5]
;
Perin, Marco A.
[1]
Total Authors: 7
|
| Affiliation: | [1] Hosp Israelita Albert Einstein, Dept Intervent Cardiol, Sao Paulo, SP - Brazil
[2] Western Univ, Schulich Sch Med & Dent, London Hlth Sci Ctr, 339 Windermere Rd, London, ON N6A 5A5 - Canada
[3] Dante Pazzanese Inst Cardiol, Dept Intervent Cardiol, Sao Paulo - Brazil
[4] Cardiovasc Res Ctr, Sao Paulo, SP - Brazil
[5] Cleveland Clin, Dept Cardiovasc Med, Cleveland, OH 44106 - USA
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | CARDIOVASCULAR REVASCULARIZATION MEDICINE; v. 21, n. 5, p. 640-646, MAY 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Background/purpose: This study sought to determine the diagnostic accuracy of 320-row computed tomography (320CT) for characterizing coronary atherosclerotic plaques in comparison with optical coherence tomography (OCT). Methods/materials: From 32 patients, 42 coronary segments were evaluated and co-registered by both 320CT and OCT. 320CT vulnerable plaque characteristics included low attenuation plaque (LAP) (<30HU), napkin-ring sign (NRS), positive remodeling (PR) and spotty calcification (SC). The presence of macrophage, neovascularization and cholesterol crystals was also determined by OCT. Results: Minimal lumen area was 2.78 +/- 1.23 mm by OCT and 3.29 +/- 1.49 mm by 320CT (p < 0.001). Noncalcified plaques were classified accordingly by both methods in 88.2% of the cases (p = 0.005). There was no association between any 320CT plaque type and OCT fibroatheroma (p = 0.62). The combination of 2 or more of the 320CT vulnerable plaque characteristics was associated with the presence of macrophage (74.2 vs. 25.8%; p = 0.034) and cholesterol crystals (85.7 vs. 14.3%; p = 0.04), but not with neovascularization (p = 0.65). The presence of all four characteristics demonstrated an accuracy of 75.1% for detecting OCT fibroatheroma. Conclusions: 320CT is useful for non-invasive evaluation of calcified and noncalcified tissue characteristics of coronary atheroma. The combination of all four 320CT vulnerable plaque characteristics provided the highest accuracy for detecting fibroatheromas. ITALIC]Summary: 320CT is useful for non-invasive evaluation of calcified and noncalcified tissue characteristics of coronary atheroma. The combination of all 320CT vulnerable plaque characteristics (low attenuation plaque (<30HU), napkin-ring sign, positive remodeling and spotty calcification) provided the highest accuracy for detecting fibroatheromas compared to optical coherence tomography. (C) 2019 Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 15/02239-6 - Coronary Atherosclerosis Evaluation by Intracoronary Optical Coherence Tomography and 320-row Coronary Computed Tomography: Correlation and Concordance of the Findings of Both Methods. |
| Grantee: | Luiz Fernando Ybarra Martins de Oliveira |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 15/00485-0 - Coronary Atherosclerosis Evaluation by Intracoronary Optical Coherence Tomography and 320-row Coronary Computed Tomography: Correlation and Concordance of the Findings of Both Methods. |
| Grantee: | Marco Antonio Perin |
| Support Opportunities: | Regular Research Grants |