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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Representation of Olfactory Information in Organized Active Neural Ensembles in the Hypothalamus

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Author(s):
de Andrade Carvalho, Vinicius Miessler [1, 2, 3] ; Nakahara, Thiago Seike [1, 2] ; de Andrade Souza, Mateus Augusto [1, 2] ; Cardozo, Leonardo Minete [1, 2] ; Trintinalia, Guilherme Ziegler [1, 2] ; Pissinato, Leonardo Granato [1, 2] ; Venancio, Jose Otavio [1] ; Stowers, Lisa [3] ; Papes, Fabio [1]
Total Authors: 9
Affiliation:
[1] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Rua Monteiro Lobato 255, BR-13083862 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Biol, Grad Program Genet & Mol Biol, Rua Monteiro Lobato 255, BR-13083862 Campinas, SP - Brazil
[3] Scripps Res, Dept Cell Biol, 10550 N Torrey Pines Rd, La Jolla, CA 92037 - USA
Total Affiliations: 3
Document type: Journal article
Source: CELL REPORTS; v. 32, n. 8 AUG 25 2020.
Web of Science Citations: 0
Abstract

The internal representation of sensory information via coherent activation of specific pathways in the nervous system is key to appropriate behavioral responses. Little is known about how chemical stimuli that elicit instinctive behaviors lead to organized patterns of activity in the hypothalamus. Here, we study how a wide range of chemosignals form a discernible map of olfactory information in the ventromedial nucleus of the hypothalamus (VMH) and show that different stimuli entail distinct active neural ensembles. Importantly, we demonstrate that this map depends on functional inputs from the vomeronasal organ. We present evidence that the spatial locations of active VMH ensembles are correlated with activation of distinct vomeronasal receptors and that disjunct VMH ensembles exhibit differential projection patterns. Moreover, active ensembles with distinct spatial locations are not necessarily associated with different behavior categories, such as defensive or social, calling for a revision of the currently accepted model of VMH organization. (AU)

FAPESP's process: 10/01211-7 - Molecular study of receptors in the mammalian Olfactory System.
Grantee:Leonardo Minete Cardozo
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/04026-1 - Functional and Molecular Characterization of OR class receptors expressed in the mammalian Vomeronasal Organ.
Grantee:Thiago Seike Picoreti Nakahara
Support type: Scholarships in Brazil - Master
FAPESP's process: 13/03372-6 - Molecular and functional investigation of Polycomb Group proteins and their involvement in olfactory neurogenesis
Grantee:Mateus Augusto de Andrade Souza
Support type: Scholarships in Brazil - Master
FAPESP's process: 15/50371-0 - Mechanisms underkying how social experience alters hormone levels, sensory signaling and behavior
Grantee:Fabio Papes
Support type: Regular Research Grants
FAPESP's process: 12/01689-0 - Molecular study of the epigenome involved in the regulation of olfactory receptor gene expression
Grantee:Vinicius Miessler de Andrade Carvalho
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 14/25594-3 - Optogenetic manipulation of olfactory circuits
Grantee:Vinicius Miessler de Andrade Carvalho
Support type: Scholarships abroad - Research Internship - Doctorate (Direct)
FAPESP's process: 09/00473-0 - Molecular biology of the olfactory system in mammals: study on the detection of odors and their neural representation in the brain
Grantee:Fabio Papes
Support type: Research Grants - Young Investigators Grants