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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sampling and processing blood samples within the South American Youth/Child cARdiovascular and Environmental (SAYCARE) Study

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Author(s):
Lopez, Graciela [1] ; Serruya, Raphael Assali [2] ; Barchuk, Magali [1] ; Gaitan-Charry, Diego [3] ; Torres-Leal, Francisco Leonardo [4] ; Moreno, Luis Alberto [5] ; Delgado, Carlos Alberto [6] ; Carvalho, Heraclito Barbosa [2] ; Ferreira De Moraes, Augusto Cesar [7, 2] ; Berg, Gabriela [1, 8]
Total Authors: 10
Affiliation:
[1] Univ Buenos Aires, Fac Farm & Bioquim, Bioquim Clin 1, Buenos Aires, DF - Argentina
[2] Univ Sao Paulo, Fac Med, YCARE Youth Child & cArdiovasc Risk & Evironm Res, Sao Paulo, SP - Brazil
[3] Univ Antioquia, Escuela Nutr & Dietet, Medellin - Colombia
[4] Univ Fed Piaui, Ctr Hlth Sci, DOMEN Metab Dis Exercise & Nutr Res Grp, Teresina - Brazil
[5] Univ Zaragoza, Fac Hlth Sci, GENUD Growth Exercise Nutr & Dev Res Grp, Inst Agroalimentario Aragon IA2, Zaragoza - Spain
[6] Univ Nacl Mayor San Marcos, Univ Peruana Cayetano Heredia, Dept Pediat, Fac Med, Inst Nacl Salud Nino, Lima - Peru
[7] Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, Sao Paulo, SP - Brazil
[8] Univ Buenos Aires, Fac Farm & Bioquim, CONICET, Buenos Aires, DF - Argentina
Total Affiliations: 8
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 10, n. 1 JAN 20 2020.
Web of Science Citations: 0
Abstract

Obesity and overweight in children and adolescents is increasing rapidly worldwide; however, scarce data have been reported from South America countries. With the purpose of assessing hyperlipidemia, insulin resistance and chronic inflammation, the evaluation of blood biomarkers such as glucose, lipoproteins and chronic inflammation proteins is required. In the context of the SAYCARE study, in children and adolescents (3 to 18 years) from seven South American cities, our aim was to assess the impact of pre analytical conditions on different biomarkers evaluated in 474 fresh serum samples, in different country centers. We also evaluated the stability according to time and frozen storage within this study across the concordance of the results obtained from the 49 blood samples measured in three different centers. Significant correlations as well as concordance were observed in TG, Total-C, HDL-C and glucose between Buenos Aires and SAo Paulo. The samples evaluated in Teresina and SAo Paulo presented similar results, with exception of total cholesterol. We observed acceptable concordance between Buenos Aires vs SAo Paulo and Teresina vs SAo Paulo, suggesting that samples could be processed in each of these centers. This concordance is a consequence of the strict pre analytical conditions previously established in the SAYCARE study. (AU)

FAPESP's process: 17/20317-0 - New frontiers in pediatric nutritional and cardiovascular health: methods development to assess the double burden of malnutrition and ideal cardiovascular health in low-in-middle income countries - SAYCARE cohort study
Grantee:Augusto César Ferreira de Moraes
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 15/11406-3 - SAYCARE study: South American youth/child cardiovascular and environmental study
Grantee:Heraclito Barbosa de Carvalho
Support type: Research Grants - Visiting Researcher Grant - International
FAPESP's process: 15/18876-5 - Evaluation of blood samples stability after transportation in a multicenter study in South America
Grantee:Raphael Assali Serruya
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 14/11468-6 - Design and implementation of the SAYCARE Study: South American Youth/Child Cardiovascular and Environmental Study
Grantee:Heraclito Barbosa de Carvalho
Support type: Regular Research Grants
FAPESP's process: 19/02617-1 - New frontiers in pediatric nutritional and cardiovascular health: Methods development to assess the double burden of malnutrition and ideal cardiovascular health in low-in-middle income countries - SAYCARE Cohort Study
Grantee:Augusto César Ferreira de Moraes
Support type: Scholarships in Brazil - Young Researchers