New frontiers in pediatric nutritional and cardiovascular health: methods development to assess the double burden of malnutrition and ideal cardiovascular health in low-in-middle income countries - SAYCARE cohort study

• Grant number: 17/20317-0
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: March 01, 2019
• End date: July 31, 2022
• Field of knowledge: Health Sciences - Collective Health - Epidemiology
• Principal Investigator: Augusto César Ferreira de Moraes
• Grantee: Augusto César Ferreira de Moraes
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Heraclito Barbosa de Carvalho ; Marcus Vinicius Nascimento Ferreira ; Maria Paula Maciel Rando Meirelles
• Associated scholarship(s): 21/14187-1 - Reliability and validation of a questionnaire on barriers and facilitators perceived to reduce sedentary behavior, BP.MS; 21/00450-2 - Association between breakfast and increased consumption of unhealthy foods SAYCARE Cohort Study, BP.IC; 19/24224-1 - Prevalence and incidence of high blood pressure and its association with environmental and lifestyle factors in South American children: SAYCARE cohort study, BP.DR; + associated scholarships 20/04575-1 - Harmonization and quality control of anthropometric measurements in children in a multicenter study in South America, BP.TT; 20/02533-0 - Harmonization and quality control of blood samples in children in a multicenter study in South America, BP.TT; 19/26864-8 - Harmonization and quality control of anthropometric measurements in children in a multicenter study in South America, BP.TT; 19/10852-0 - Sugar-sweetened beverage intake in South American children: validation of a food frequency questionnaire and consumption pattern, BP.IC; 18/19068-8 - Reliability and validation of inflammatory diet index in children and adolescents: SAYCARE Study, BP.MS; 19/13527-3 - Body image and weight: association between parents' perception and the body adiposity of South American children: SAYCARE Cohort Study, BP.IC; 19/07624-6 - REDCap: web platform for collecting and managing data in a multicenter study in South America - SAYCARE Cohort Study, BP.TT; 19/10766-7 - Harmonization and quality control of anthropometric measures in children in a multicenter study in South America, BP.TT; 19/02617-1 - New frontiers in pediatric nutritional and cardiovascular health: Methods development to assess the double burden of malnutrition and ideal cardiovascular health in low-in-middle income countries - SAYCARE Cohort Study, BP.JP - associated scholarships

Abstract

This is a multicenter cohort (24-month) in a sample of children. This project will be developed in São Paulo and five other cities in South America: Buenos Aires (Argentina), Lima (Peru), Medellin (Colombia) and Teresina (Brazil). The sample size was previously calculated with the main objective to evaluate if there is an association between "Double Burden of Malnutrition" (mainly exposure) and "Ideal Cardiovascular Health" (mainly outcome), for which the baseline cohort sample size will consist of at least 690 children per city, totaling 4,140 subjects of both sexes age-range 5 to 7 years old, who will be follow-up in two moments (12 months and 24 months). The sample will be recruited by complex sample selection in public and private schools of each city. At each visit we will be assessed: to obtain information from: social and environmental factors, family environment, food intake, preference and food choices, physical activity and sedentary behaviors body composition, cardiovascular health biomarkers, insulin resistance, pro-inflammatory and anti-inflammatory markers and iron and ferritin serum levels. To analyze the data, we will use: I) descriptive analyzes (mean, median, proportions, 95% confidence intervals and interquartile range); II) hypothesis testing (comparisons of quantitative and qualitative variables); III) measuring disease and exposure occurrence (measures of prevalence and incidence); IV) measuring associations between exposures and outcome [by univariate and multivariate analyzes prevalence ratio and/or ² coefficient (baseline data) and relative risk and/or ² coefficient (follow-up data)]. The statistical significance adopted will be alpha 5%. It is expected that the project can: I) to identify the strength of associations between "Double Burden of Malnutrition" and "Ideal Cardiovascular Health"; II) what is the most accurate "Double Burden of Malnutrition" diagnostic method; III) to identify longitudinal changes in pattern of "Ideal Cardiovascular Health" during childhood; as well as, to identify the mediator/modifier effects of environmental, socioeconomic and behavioral variables on the longitudinal pattern this outcome. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA DE MORAES, AUGUSTO CESAR; VILANOVA-CAMPELO, REGINA CELIA; TORRES-LEAL, FRANCISCO LEONARDO; CARVALHO, HERACLITO BARBOSA. Is Self-Reported Physical Fitness Useful for Estimating Fitness Levels in Children and Adolescents? A Reliability and Validity Study. MEDICINA-LITHUANIA, v. 55, n. 6, JUN 2019. (14/11468-6, 17/20317-0, 19/02617-1)

ARAUJO-MOURA, KEISYANNE; SOUZA, LETICIA GABRIELLE; MELLO, GABRIELE LUZ; FERREIRA DE MORAES, AUGUSTO CESAR. Blood pressure measurement in pediatric population: comparison between automated oscillometric devices and mercury sphygmomanometers-a systematic review and meta-analysis. EUROPEAN JOURNAL OF PEDIATRICS, v. 181, n. 1, JUL 2021. (19/10852-0, 19/13527-3, 19/24224-1, 17/20317-0, 19/02617-1)

FERREIRA DE MORAES, AUGUSTO CESAR; VINICIUS NASCIMENTO-FERREIRA, MARCUS; DE MORAES FORJAZ, CLAUDIA LUCIA; CARLOS ARISTIZABAL, JUAN; AZZARETTI, LETICIA; NASCIMENTO JUNIOR, WALTER VIANA; MIGUEL-BERGES, MARIA L.; SKAPINO, ESTELA; DELGADO, CARLOS; MORENO, LUIS A.; et al. Reliability and validity of a sedentary behavior questionnaire for South American pediatric population: SAYCARE study. BMC MEDICAL RESEARCH METHODOLOGY, v. 20, n. 1, JAN 10 2020. (16/18436-8, 14/11468-6, 17/20317-0, 19/02617-1, 17/11732-3, 15/11406-3)

COLLESE, TATIANA SADALLA; FERREIRA DE MORAES, AUGUSTO CESAR; RENDO-URTEAGA, TARA; LUZIA, LIANIA ALVES; DE CARVALHO RONDO, PATRICIA HELEN; LOBO MARCHIONI, DIRCE MARIA; CARVALHO, HERACLITO BARBOSA. The Validity of Children's Fruit and Vegetable Intake Using Plasma Vitamins A, C, and E: The SAYCARE Study. NUTRIENTS, v. 11, n. 8, AUG 2019. (19/02617-1, 16/13922-1, 17/20317-0)

MEDEIROS-OLIVEIRA, VANESSA CASSIA; VIANA, RAYTTA SILVA; DE OLIVEIRA, ARICLECIO CUNHA; NASCIMENTO-FERREIRA, MARCUS VINICIUS; DE MORAES, AUGUSTO CESAR FERREIRA. Are sleep time and quality associated with inflammation in children and adolescents? A systematic review. PREVENTIVE MEDICINE REPORTS, v. 35, p. 6-pg., 2023-10-01. (17/20317-0, 19/02617-1)

LOPEZ, GRACIELA; SERRUYA, RAPHAEL ASSALI; BARCHUK, MAGALI; GAITAN-CHARRY, DIEGO; TORRES-LEAL, FRANCISCO LEONARDO; MORENO, LUIS ALBERTO; DELGADO, CARLOS ALBERTO; CARVALHO, HERACLITO BARBOSA; FERREIRA DE MORAES, AUGUSTO CESAR; BERG, GABRIELA. Sampling and processing blood samples within the South American Youth/Child cARdiovascular and Environmental (SAYCARE) Study. SCIENTIFIC REPORTS, v. 10, n. 1, JAN 20 2020. (17/20317-0, 15/11406-3, 15/18876-5, 14/11468-6, 19/02617-1)

NASCIMENTO-FERREIRA, MARCUS VINICIUS; FERREIRA DE MORAES, AUGUSTO CESAR; RENDO-URTEAGA, TARA; TOAZZA OLIVEIRA, PAULO VINICIUS; MORENO, LUIS A.; CARVALHO, HERACLITO BARBOSA. Impact of methodological approaches in the agreement between subjective and objective methods for assessing screen time and sedentary behavior in pediatric population: a systematic review. NUTRICION HOSPITALARIA, v. 36, n. 2, p. 449-462, MAR-APR 2019. (17/11732-3, 19/02617-1, 15/11406-3, 17/20317-0, 14/25233-0, 16/18436-8, 14/13367-2, 15/14319-4, 14/11468-6)

NASCIMENTO-FERREIRA, MARCUS VINICIUS; FERREIRA DE MORAES, AUGUSTO CESAR; MARIA MONSALVE-ALVAREZ, JULIA; TELLO, FLORENCIA; ARAUJO-MOURA, KEISYANNE; DELGADO, CARLOS A.; BOVE, MARIA ISABEL; MORENO, LUIS A.; CARVALHOL, HERACLITO. Psychometric properties of 4-item questionnaire for sleep habits and time in a South American paediatric population. SLEEP SCIENCE, v. 14, n. 2, p. 169-174, 2021. (15/11406-3, 19/02617-1, 16/18436-8, 14/11468-6, 17/11732-3, 17/20317-0)