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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Age-related assessment of diffusion parameters in specific brain tracts correlated with cortical thinning

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Author(s):
Pinto, Maira Siqueira [1] ; dos Santos, Antonio Carlos [2] ; Salmon, Carlos Ernesto Garrido [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, InBrain Lab, Dept Phys, Fac Philosophy Sci & Letters Ribeirao Preto, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dept Internal Med, Ribeirao Preto Med Sch, Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: NEUROLOGICAL SCIENCES; v. 42, n. 5 SEP 2020.
Web of Science Citations: 0
Abstract

The aging process is associated with many brain structural alterations. These changes are not associated with neuronal loss but can be due to cortical structural changes that may be related to white matter (WM) structural alterations. In this study, we evaluated age-related changes in WM and gray matter (GM) parameters and how they correlate for specific brain tracts in a cohort of 158 healthy individuals, aged between 18 and 83 years old. In the tract-cortical analysis, cortical regions connected by tracts demonstrated similar thinning patterns for the majority of tracts. Additionally, a significant relationship was found between mean cortical thinning rate with fractional anisotropy (FA) and mean diffusivity (MD) alteration rates. For all tracts, age was the main effect controlling diffusion parameter alterations. We found no direct correlations between cortical thickness and FA or MD, except for in the fornix, for which the subcallosal gyrus thickness was significantly correlated to FA and MD (p< 0.05 FDR corrected). Our findings lead to the conclusion that alterations in the WM diffusion parameters are explained by the aging process, also associated with cortical thickness changes. Also, the alteration rates of the structural parameters are correlated to the different brain tracts in the aging process. (AU)

FAPESP's process: 15/26227-7 - Study of structural brain connectivity in healthy aging based on tracts
Grantee:Maíra Siqueira Pinto
Support Opportunities: Scholarships in Brazil - Master