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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Trends in nanoformulations for atopic dermatitis treatment

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Author(s):
Ramos Campos, Estefania Vangelie [1] ; Proenca, Patricia Luiza De Freitas [2] ; Doretto-Silva, Lorena [1] ; Andrade-Oliveira, Vinicius [1] ; Fraceto, Leonardo Fernandes [2] ; de Araujo, Daniele Ribeiro [1]
Total Authors: 6
Affiliation:
[1] Fed Univ ABC, Human & Nat Sci Ctr, Santo Andre, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Sci & Technol, Dept Environm Engn, Sorocaba, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: Expert Opinion on Drug Delivery; v. 17, n. 11 AUG 2020.
Web of Science Citations: 0
Abstract

Introduction Immunological skin dysfunctions trigger the synthesis and release of inflammatory cytokines, which induce recurrent skin inflammation associated with chronic itching, inefficient barrier behavior, and reduced skin hydration. These features characterize a multifactorial chronic inflammatory disease atopic dermatitis (AD). AD therapy includes anti-inflammatory drugs and immunosuppressors as well as non-pharmacological alternatives such as emollients, moisturizers, and lipids (ceramides, phospholipids) for modulating the skin hydration and the barrier repair. However, these treatments are inconvenient with low drug skin penetration and insufficient maintenance on the application site. Areas covered Nanotechnology-based therapies can be a great strategy to overcome these limitations. Considering the particular skin morphological organization, SC lipid matrix composition, and immunological functions/features related to nanocarriers, this review focuses on recent developments of nanoparticulate systems (polymeric, lipid-based, inorganic) as parent or hybrid systems including their chemical composition, physico-chemical and biopharmaceutical properties, and differential characteristics that evaluate them as new effective drug-delivery systems for AD treatment. Expert opinion Despite the several innovative formulations, research in nanotechnology-based carriers should address specific aspects such as the use of moisturizers associated to pharmacological therapies, toxicity studies, scale-up production processes and the nanocarrier influence on immunological response. These approaches will help researchers choose the most appropriate nanocarrier system and widen nanomedicine applications and commercialization. (AU)

FAPESP's process: 19/20303-4 - Thermosensitive organogels as strategies for the treatment of inflammatory processes: from supramolecular structure to pharmacological evaluation
Grantee:Daniele Ribeiro de Araujo
Support Opportunities: Regular Research Grants
FAPESP's process: 17/24402-1 - pH AND TEMPERATURE SENSITIVE DRUG NANOCARRIERS FOR SKIN APPLICATIONS
Grantee:Estefânia Vangelie Ramos Campos
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 19/05100-0 - Evaluation of the biological activity of topical formulations of budesonide in inflammatory skin models
Grantee:Estefânia Vangelie Ramos Campos
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor