Resveratrol isoforms and conjugates: A review from biosynthesis in plants to elimination from the human body

Author(s)

Riccio, Bruno V. F. ^[1] ; Sposito, Larissa ^[1] ; Carvalho, Gabriela C. ^[1] ; Ferrari, Priscileila C. ^[2] ; Chorilli, Marlus ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Dept Drugs & Med, Sch Pharmaceut Sci, Araraquara Jau Hwy, Km 1, BR-14800901 Araraquara, SP - Brazil

^[2] Ponta Grossa State Univ UEPG, Dept Pharmaceut Sci, Ponta Grossa, Parana - Brazil

• Document type: Review article
• Source: ARCHIV DER PHARMAZIE; v. 353, n. 12 SEP 2020.
• Web of Science Citations: 0

Abstract

The natural isomers of resveratrol,cis-andtrans-resveratrol, are natural phenolic substances synthetized via the shikimate pathway and found in many sources, including grapes, peanuts, blackberries, pistachios, cacao, cranberries, and jackfruits. They have functional and pharmacological properties such as anticarcinogenic, antidiabetic, anti-inflammatory, and cardioprotective activities. The aim of this article is to review the data published on resveratrol and its isomers, and their biosynthesis in plants, food sources, health and toxic effects, and the excretion of their metabolites. Due to its contribution to the promotion of human health, it is convenient to gather more knowledge about its functional properties, food sources, and the interactions with the human body during the processes of eating, digestion, absorption, biotransformation, and excretion, to combine this information to improve the understanding of these substances. (AU)

• FAPESP's process: 19/00164-0 - Trans-resveratrol solid dispersions incorporated into polyvinylpyrrolidone membranes for cutaneous application: development, characterization and biological evaluation in vitro and in vivo
• Grantee: Bruno Vincenzo Fiod Riccio
• Support Opportunities: Scholarships in Brazil - Master