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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oxidative and nitrosative stresses in cerebral malaria: can we target them to avoid a bad prognosis?

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Author(s):
Santos Pereira, Domingos Magno [1] ; Carvalho Junior, Alexsander Rodrigues [1] ; da Costa Brito Lacerda, Eliza Maria [1] ; Nascimento da Silva, Luis Claudio [1] ; Farias Marinho, Claudio Romero [2] ; Andre, Eunice [3] ; Fernandes, Elizabeth Soares [1, 4, 5]
Total Authors: 7
Affiliation:
[1] Univ CEUMA, Programa Posgrad, Sao Luis, MA - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, Sao Paulo, SP - Brazil
[3] Univ Fed Parana, Dept Farmacol, Curitiba, Parana - Brazil
[4] Inst Pesquisa Pele Pequeno Principe, Curitiba, Parana - Brazil
[5] Fac Pequeno Principe, Curitiba, Parana - Brazil
Total Affiliations: 5
Document type: Review article
Source: Journal of Antimicrobial Chemotherapy; v. 75, n. 6, p. 1363-1373, JUN 2020.
Web of Science Citations: 0
Abstract

There is currently a global effort to reduce malaria morbidity and mortality. However, malaria still results in the deaths of thousands of people every year. Malaria is caused by Plasmodium spp., parasites transmitted through the bite of an infected female Anopheles mosquito. Treatment timing plays a decisive role in reducing mortality and sequelae associated with the severe forms of the disease such as cerebral malaria (CM). The available antimalarial therapy is considered effective but parasite resistance to these drugs has been observed in some countries. Antimalarial drugs act by increasing parasite lysis, especially through targeting oxidative stress pathways. Here we discuss the roles of reactive oxygen species and reactive nitrogen intermediates in CM as a result of host-parasite interactions. We also present evidence of the potential contribution of oxidative and nitrosative stress-based antimalarial drugs to disease treatment and control. (AU)

FAPESP's process: 18/20468-0 - Recrudescence of the malaria during pregnancy: effects and mechanisms
Grantee:Cláudio Romero Farias Marinho
Support Opportunities: Regular Research Grants