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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Preoperative Differentiation of Benign and Malignant Non-epithelial Ovarian Tumors: Clinical Features and Tumor Markers

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Author(s):
Tiago Augusto Gomes [1] ; Elizabeth Aparecida Campos [2] ; Adriana Yoshida [3] ; Luís Otavio Sarian [4] ; Liliana Aparecida Lucci de Angelo Andrade [5] ; Sophie Françoise Derchain [6]
Total Authors: 6
Affiliation:
[1] Universidade Estadual de Campinas. Faculty of Medical Sciences. Department of Obstetrics and Gynecology - Brasil
[2] Universidade Estadual de Campinas. Hospital da Mulher Prof. Dr. José Aristodemo Pinotti. Laboratory of Experimental Pathology - Brasil
[3] Universidade Estadual de Campinas. Faculty of Medical Sciences. Department of Obstetrics and Gynecology - Brasil
[4] Universidade Estadual de Campinas. Faculty of Medical Sciences. Department of Obstetrics and Gynecology - Brasil
[5] universidade Estadual de Campinas. Faculty of Medical Sciences. Department of Pathology - Brasil
[6] Universidade Estadual de Campinas. Faculty of Medical Sciences. Department of Obstetrics and Gynecology - Brasil
Total Affiliations: 6
Document type: Journal article
Source: Revista Brasileira de Ginecologia e Obstetrícia; v. 42, n. 9, p. 555-561, 2020-10-23.
Abstract

Abstract Objective To evaluate the role of clinical features and preoperativemeasurement of cancer antigen 125 (CA125), human epididymis protein(HE4), and carcinoembryonic antigen (CEA) serum levels in women with benign and malignant non-epithelial ovarian tumors. Methods One hundred and nineteen consecutive women with germ cell, sex cordstromal, and ovarian leiomyomas were included in this study. The preoperative levels of biomarkers were measured, and then surgery and histopathological analysis were performed. Information about the treatment and disease recurrence were obtained from the medical files of patients. Results Our sample included 71 women with germ cell tumors (64 benign and 7 malignant), 46 with sex cord-stromal tumors (32 benign and 14 malignant), and 2 with ovarian leiomyomas. Among benign germ cell tumors, 63 were mature teratomas, and, amongmalignant, fourwere immatureteratomas. Themost common tumors in the sex cordstromal group were fibromas (benign) and granulosa cell tumor (malignant). The biomarker serum levels were not different among benign andmalignant non-epithelial ovarian tumors. Fertility-sparing surgeries were performed in 5 (71.4%) women with malignant germ cell tumor. Eleven (78.6%) patients with malignant sex cord-stromal tumors were treated with fertility-sparing surgeries. Five women (71.4%) with germ cell tumors and only 1 (7.1%) with sex cord-stromal tumor were treated with chemotherapy. One woman with germ cell tumor recurred and died of the disease and one woman with sex cord-stromal tumor recurred. Conclusion Non-epithelial ovarian tumors were benign in the majority of cases, and the malignant caseswere diagnosed at initial stages with good prognosis. Themeasurements of CA125, HE4, and CEA serum levels were not useful in the preoperative diagnosis of these tumors. (AU)

FAPESP's process: 12/15059-8 - Evaluation of biomarkers in the detection of malignant neoplasia in women with adnexal mass
Grantee:Sophie Françoise Mauricette Derchain
Support Opportunities: Regular Research Grants