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Comparing risk of malignancy indexes with the simple rules of ultrasonography iota in adnexal masses preoperative differentiation

Grant number: 14/18240-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2014
Effective date (End): November 30, 2015
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal researcher:Sophie Françoise Mauricette Derchain
Grantee:Nathália Lonardoni Crozatti Ferreira
Home Institution: Centro de Atenção Integral à Saúde da Mulher (CAISM). Hospital da Mulher Professor Doutor José Aristodemo Pinotti. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Ovarian cancer represents 2% of cancers in general. For detecting ovarian cancer in early stages, the most commonly used test is the ultrasound. It is estimated that between 2.7% to 8% of women have ovarian cysts or pelvic masses. For characterizing adnexal tumor benign or malignant it is necessary to use efficient criteria which can be based exclusively on aspects of ultrasound markers or take into account tumor markers and clinical data. This study is part of a research line that assesses tumor markers and imaging methods in the discrimination of adnexal masses (Fapesp 2012/15059-8). The adnexal masses preoperative evaluation contributes to give proper care in reference centers to women with malignancies and to offer conservatively care to women with benign neoplasms, like laparoscopy. The Risk of Malignancy Indicex (RMI) take into account the woman's menopausal status, serum CA 125 and ultrasound aspects. The different RMIs are used in adnexal masses preoperative discrimination, each RMIs scores these variables differently. However, the CA 125 is the value that most affects the RMI calculation, therefore, the CA 125 damaging the RMI accuracy. Recently, the simple rules of the International Ovarian Tumor Analysis (IOTA) have been developed, it uses five malignancy criteria and five benignity criteria for ovarian tumors. It hasn´t been found in the literature an article which compares the IRM to the simple rules of the IOTA in Brazilian women. Therefore, this study aims to compare sensitivity, specificity, positive predictive value and negative predictive value of RMI to simple rules of IOTA. This is a cross-sectional study that has a sample size of 400 women, among which 120 have ovarian cancer. The independent variables are: menopausal status, ultrasound adnexal masses morphological features and serum CA 125 value. The dependent variable is the result histopathological test. All women which is confirmed adnexal mass on ultrasound examination CAISM are included in this study. All women with an indication for surgery and who fail to perform the procedure are excluded in this study. All information necessary to the study are recorded on a form for data collection developed specifically for this study. (AU)

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