| Full text | |
| Author(s): Show less - |
Oliveira, Marilene Silva
[1, 2, 3]
;
Chorociejus, Gabriel
[1]
;
Angeli, Jose Pedro F.
[4]
;
Vila Verde, Giuliana
[3]
;
Aquino, Gilberto L. B.
[3]
;
Ronsein, Graziella E.
[1]
;
Oliveira, Mauricio Cesar Bof de
[5]
;
Barbosa, Livea F.
[1]
;
Medeiros, Marisa H. G.
[1]
;
Greer, Alexander
[6, 7]
;
Di Mascio, Paolo
[1]
Total Authors: 11
|
| Affiliation: | [1] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo, SP - Brazil
[2] Inst Fed Educ Ciencia & Tecnol Goiano, Dept Agroquim, Campus Rio Verde, Rio Verde, Go - Brazil
[3] Univ Estadual Goias, Campus Anapolis Ciencias Exatas & Tecnol Henr San, BR-75001970 Anapolis, Go - Brazil
[4] Univ Wurzburg, Rudolf Virchow Ctr Translat Bioimaging, D-97080 Wurzburg - Germany
[5] Policia Fed, Setor Tecn Cient, BR-05038090 Sao Paulo, SP - Brazil
[6] CUNY Brooklyn Coll, Dept Chem, Brooklyn, NY 11210 - USA
[7] CUNY, PhD Program Chem, Grad Ctr, 365 Fifth Ave, New York, NY 10016 - USA
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES; v. 19, n. 11, p. 1590-1602, NOV 1 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Studies have previously shown that anthracene and naphthalene derivatives serve as compounds for trapping and chemically generating singlet molecular oxygen {[}O-2((1)Delta(g))], respectively. Simple and efficient synthetic routes to anthracene and naphthalene derivatives are needed, for improved capture and release of O-2((1)Delta(g)) in cellular environments. Because of this need, we have synthesized a dihydroxypropyl amide naphthlene endoperoxide as a O-2((1)Delta(g)) donor, as well as five anthracene derivatives as O-2((1)Delta(g)) acceptor. The anthracene derivatives bear dihydroxypropyl amide, ester, and sulfonate ion end groups connected to 9,10-positions by way of unsaturated (vinyl) and saturated (ethyl) bridging groups. Heck reactions were found to yield these six compounds in easy-to-carry out 3-step reactions in yields of 50-76%. Preliminary results point to the potential of the anthracene compounds to serve as O-2((1)Delta(g)) acceptors and would be amenable for future use in biological systems to expand the understanding of O-2((1)Delta(g)) in biochemistry. (AU) | |
| FAPESP's process: | 12/12663-1 - Singlet molecular oxygen and peroxides in chemical biology |
| Grantee: | Paolo Di Mascio |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 13/07937-8 - Redoxome - Redox Processes in Biomedicine |
| Grantee: | Ohara Augusto |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |