| Full text | |
| Author(s): Show less - |
Zboril, Sabrina
[1]
;
Schmidt, Andre P.
[2, 3, 4, 5]
;
Oses, Jean P.
[6]
;
Wiener, Carolina D.
[7]
;
Portela, V, Luis
;
Souza, Diogo O.
[8]
;
Auler Junior, Jose O. C.
[9]
;
Carmona, Maria J. C.
[9]
;
Fugita, Mariana S.
[1]
;
Flor, Patricia B.
[1]
;
Cortopassi, Silvia R. G.
[1]
Total Authors: 11
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Surg, Sao Paulo, SP - Brazil
[2] Univ Fed Rio Grande do Sul UFRGS, Dept Biochem, Inst Ciencias Basicas Saude ICBS, Porto Alegre, RS - Brazil
[3] Univ Fed Rio Grande do Sul, Dept Anesthesia & Perioperat Med, Hosp Clin Porto Alegre, Porto Alegre, RS - Brazil
[4] UFCSPA, Dept Anesthesia, Santa Casa Porto Alegre, Porto Alegre, RS - Brazil
[5] Hosp Nossa Senhora da Conceicao, Dept Anesthesia, Porto Alegre, RS - Brazil
[6] Univ Fed Mato Grosso do Sul UFMS, Inst Biociencias, Setor Bioquim, Postgrad Program Biochem & Mol Biol, Campo Grande, MS - Brazil
[7] Univ Catolica Pelotas, Postgrad Program Hlth & Behav, Pelotas, RS - Brazil
[8] Portela, Luis, V, Univ Fed Rio Grande do Sul UFRGS, Dept Biochem, Inst Ciencias Basicas Saude ICBS, Porto Alegre, RS - Brazil
[9] Univ Sao Paulo, Fac Med, Dept Cirurgia, Disciplina Anestesiol, Sao Paulo, SP - Brazil
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | VETERINARY ANAESTHESIA AND ANALGESIA; v. 47, n. 6, p. 740-747, NOV 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Objective Postoperative cognitive dysfunction (POCD) may be related to brain injury. S100B protein and neuronspecific enolase (NSE) have been investigated as potential biochemical markers of neural cell injury in animals and humans. This study aimed to investigate the association between POCD, brain injury and serum concentrations of S100B and NSE after periodontal surgery in aged dogs. Study design Prospective observational animal study. Animals A total of 24 male and female dogs undergoing periodontal surgery. Methods Dogs were separated into two groups based on age: control group, 10 dogs <= 8 years and aged group, 14 dogs > 8 years. Cognitive function was measured preoperatively and on the seventh postoperative day using the Canine Cognitive Dysfunction Rating scale and the Age-Related Cognitive and Affective Disorders scale. S100B protein and NSE serum concentrations were measured before and immediately after the surgery. Results POCD was not observed after surgery in the present study. Serum concentrations of S100B and NSE were increased postoperatively in the control group but not in the aged group (p = 0.04 and 0.03, respectively). Preoperative S100B serum concentrations were significantly higher in the aged group (p = 0.01). Conclusions There was no association between POCD and high concentrations of S100B and NSE in dogs. However, increased postoperative serum concentrations of S100B and NSE were found in the control group after surgery, an effect that may indicate neural damage. (AU) | |
| FAPESP's process: | 13/05689-7 - Diagnosis of the syndrome of cognitive dysfunction in older dogs after surgery |
| Grantee: | Silvia Renata Gaido Cortopassi |
| Support Opportunities: | Regular Research Grants |