Synthesis of resilient hybrid hydrogels using UiO-66 MOFs and alginate (hydroMOFs) and their effect on mechanical and matter transport properties

Author(s)

de Lima, Hugo H. C. ^[1] ; da Silva, Cleiser T. P. ^{[1, 2]} ; Kupfer, Vicente L. ^[1] ; Rinaldi, Jaqueline de C. ^[3] ; Kioshima, Erika S. ^[3] ; Mandelli, Dalmo ^[2] ; Guilherme, Marcos R. ^{[1, 4]} ; Rinaldi, Andrelson W. ^[1]

Affiliation

^[1] State Univ Maringa UEM, Dept Chem, Rinaldi Res Grp, 5790 Colombo Ave, BR-87020900 Maringa, Parana - Brazil

^[2] Fed Univ ABC, Ctr Nat & Human Sci, 5001 Av Estados, BR-09210580 Santo Andre, SP - Brazil

^[3] State Univ Maringa UEM, Postgrad Biosci & Physiopathol PBF, 5790 Colombo Ave, BR-87020900 Maringa, Parana - Brazil

^[4] Fac Engn & Innovat Profess Tech FEITEP, Av Paranavai 1164, Parque Ind Bandeirantes, BR-87070130 Maringa, Parana - Brazil

• Document type: Journal article
• Source: Carbohydrate Polymers; v. 251, JAN 1 2021.
• Web of Science Citations: 0

Abstract

Herein, we report the preparation of an organic-inorganic hybrid hydrogel architecture using vinyl alginate and UiO-66 MOFs (metal-organic frameworks) modified with acrylic acid (AA) UiO-66AA. UiO-66 MOFs with different crystal sizes (600, 1500, and 2500 nm) were synthesized and the effect on the mechanical and transport properties of the resulting materials, such as water absorption capacity and drug release, were evaluated. HydroMOF showed higher water absorption capacity than the pure hydrogel and enhanced mechanical properties, which depend on crystal size and the amount of UiO-66AA MOF used. The initial release rate of drug (burst release) from hydroMOFs was lower when small-sized crystals or a small amount of large-sized crystals were used; thus these are essential in changing half-life values of release rates. Finally, the cytotoxicity screening successfully showed that hydroMOFs are promising biocompatible compounds proven to have the advantages of minimized burst release and mechanical robustness. (AU)

• FAPESP's process: 18/01258-5 - Novel chemical catalytic and photocatalytic processes for the direct conversion of methane and CO2 to products
• Grantee: José Maria Correa Bueno
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 19/13170-8 - New Multifunctional Metal-Organic Framework Catalysts for Mild Oxidation of Methane to Methanol
• Grantee: Cleiser Thiago Pereira da Silva
• Support Opportunities: Scholarships in Brazil - Post-Doctoral