Acute exercise increases circulating IGF-1 in Alzheimer's disease patients, but not in older adults without dementia

Author(s)

Stein, Angelica Miki ^{[1, 2]} ; Vital da Silva, Thays Martins ^{[1, 3]} ; de Melo Coelho, Flavia Gomes ^{[1, 4]} ; Rueda, Andre Veloso ^[5] ; Camarini, Rosana ^[5] ; Santos Galduroz, Ruth Ferreira ^{[1, 6]}

Affiliation

^[1] Univ Estadual Paulista UNESP, Inst Biociencias, Campus Rio Claro, Rio Claro, SP - Brazil

^[2] Fed Univ Technol Parana UTFPR, UTFPR, Campus Curitiba, Curitiba, Parana - Brazil

^[3] Inst Fed Goiano, Campus Avancado Hidrolandia, Hidrolandia, Go - Brazil

^[4] Univ Fed Triangulo Mineiro, Postgrad Program Phys Educ, Uberaba - Brazil

^[5] Univ Sao Paulo, Inst Ciencias Biomed, Dept Farmacol, Campus Sao Paulo, Sao Paulo, SP - Brazil

^[6] Univ Fed ABC UFABC, Ctr Math Comp & Cognit, Campus Sao Bernardo, Sao Bernardo Do Campo, SP - Brazil

• Document type: Journal article
• Source: Behavioural Brain Research; v. 396, JAN 1 2021.
• Web of Science Citations: 0

Abstract

Objectives: Increased Insulin-like growth factor I (IGF-1) has been associated with improvement of cognitive function in response to exercise. Evidences indicate a role for IGF-1 in beta-amyloid clearance and reducing hyperphosphorylation tau in Alzheimer's disease (AD). There is a need to investigate the IGF-1 response to exercise in AD patients due to well-known potential effects of exercise on IGF-1. The aim of this study was to examine circulating IGF-1 levels in AD patients and older adults without dementia after acute exercise and to verify the associations among cardiorespiratory fitness, cognition and IGF-1 levels. Method: Seventy-four older adults (40 older adults without dementia and 34 AD patients) participated in this study. The outcomes included IGF-1 plasma levels and performance in the submaximal exercise stress test. Secondary outcomes included cognitive functions, depressive symptoms, level of physical activity, insulin-resistance, and cholesterol. All participants performed the incremental test on a treadmill and IGF-1 was collected before and after the exercise. Results: A tendency to the difference of baseline IGF-1 plasma levels between the groups was found. After the acute exercise AD patients also presented higher levels of circulating IGF-1 compared to the Older adults without dementia. Correlations among cardiorespiratory fitness and cognitive functions were found. Conclusion: The findings suggest that AD patients and older adults respond differently to acute exercise in terms of circulating IGF-1 levels. This response seems to indicate either an IGF-1 resistance or a compensatory exerciseinduced to lower IGF-1 levels in AD patients. Cardiorespiratory fitness is associated with global cognition, executive function, attention and information processing speed. (AU)

• FAPESP's process: 13/19729-0 - Effect of aerobic training in levels of insulin-like growth factor-1 and cognitive functions in Alzheimer's Disease
• Grantee: Angelica Miki Stein
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)