| Full text | |
| Author(s): Show less - |
Padilha-Nakaghi, Luciana C.
[1]
;
Uscategui, Ricardo A. R.
[2]
;
Oliveira, Maria Emilia F.
[1]
;
Nociti, Ricardo P.
[3]
;
Macente, I, Beatrice
;
Coutinho, Leandro N.
[4]
;
Nakaghi, Eduardo Yo
[5]
;
Motta, Guilherme A.
[6]
;
Santos, Victor J. C.
[6]
;
Maciel, Giovanna S.
[6]
;
Mariano, Renata S. G.
[6]
;
Barros, Felipe F. P. C.
[7]
;
Primo, Fernando L.
[8]
;
Tedesco, Antonio C.
[9]
;
Vicente, Wilter R. R.
[6]
Total Authors: 15
|
| Affiliation: | [1] Univ Estadual Paulista UNESP, Fac Ciencias Agr & Vet FCAV, Dept Med Vet Prevent & Reprod Anim, Via Acesso Prof Paulo Donato Castellane S-N, BR-14884900 Jaboticabal, SP - Brazil
[2] Univ Fed Vales Jequitinhonha & Mucuri, Inst Ciencias Agr, Unai, MG - Brazil
[3] Univ Sao Paulo, Fac Zootecnia & Engn Alimentos FZEA, Dept Med Vet ZMV, Sao Paulo, SP - Brazil
[4] Univ Fed Rural Amazonia UFRA, Inst Saude & Prod Anim ISPA, Belem, Para - Brazil
[5] Coordenadoria Def Agr Estado Sao Paulo CDA SSA SP, Jaboticabal, SP - Brazil
[6] Macente, Beatrice, I, Univ Estadual Paulista UNESP, Fac Ciencias Agr & Vet FCAV, Dept Med Vet Prevent & Reprod Anim, Via Acesso Prof Paulo Donato Castellane S-N, BR-14884900 Jaboticabal, SP - Brazil
[7] Univ Fed Rural Rio de Janeiro, Inst Vet, Dept Med & Cirurgia Vet, Seropedica, RJ - Brazil
[8] Univ Estadual Paulista UNESP, Dept Engn Bioproc & Biotecnol, Fac Ciencias Farm Araraquara, Araraquara, SP - Brazil
[9] Univ SaoPaulo USP, Dept Quim, Lab Fotobiol & Fotomed, Ctr Nanotecnol & Engn Tecidual, Fac Filosofia Cien, Ribeirao Preto, SP - Brazil
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | Animal Reproduction Science; v. 222, NOV 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
To facilitate transcervical artificial insemination in sheep, the effects of local treatment with alpha 1-adrenergic receptor antagonists on cervix dilation and hemodynamics were evaluated. Ewes (n = 7) were subjected to oestrous synchronisation every 40 days and assigned to treatments in a Latin square experimental design (seven animals x seven periods) with a factorial treatment arrangement (A x B), Factors A (prazosin or tamsulosin) and B (1, 2, or 4 mg/animal). Ewes of the six treatment groups (P1, P2, P4, T1, T2, and T4) were administered alpha 1-adrenergic receptor antagonists while those of the control group (CG) were administered only alpha 1-adrenergic antagonist carrier agent. Distance that the transcervical catheter penetrated without cervical resistance, mean arterial pressure, and uterine artery dopplerfluxometry were evaluated before and after 30 min, 1, 2, 4, 8, and 10 h of treatment. Catheter penetration distance was greater in ewes of the T4 and P4 groups (P < 0.01), with there being a positive correlation between dose and distance (r = 0.243). The penetration distance was similar (P = 0.84) for treated groups, with the greatest penetration occurring 2, 4, and 6 h after treatment (P < 0.01). The passage into the uterine lumen was greater (P = 0.013) in ewes of the P4 (17.9 %) and T4 (19.6 %) groups. There were no effects on blood pressure or uterine blood flow (P> 0.05). These preliminary results indicate there are benefits of treatment with 4 mg/animal of tamsulosin or prazosin in catheter passage through the sheep cervix 2-6 h after administration without hemodynamic effects. (AU) | |
| FAPESP's process: | 13/50181-1 - Use of drugs containing nanocarriers with photosensitizers and/or other active compounds applied to cell therapy and treatment of central nervous system disorders |
| Grantee: | Antonio Claudio Tedesco |
| Support Opportunities: | Research Projects - Thematic Grants |