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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Design of chitosan-based particle systems: A review of the physicochemical foundations for tailored properties

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Author(s):
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Ferreira, Leonardo M. B. [1] ; dos Santos, Aline M. [2] ; Boni, Fernanda Isadora [2] ; dos Santos, Karen C. [2] ; Robusti, Leda M. Gorla [2] ; de Souza, Mauricio P. C. [2] ; Ferreira, Natalia N. [2] ; Carvalho, Suzana G. [2] ; Cardoso, Valera M. O. [2] ; Chorilli, Marlus [2] ; Cury, Beatriz S. F. [2] ; de Godoi, Denis R. M. [3] ; Gremiao, Maria Palmira D. [2]
Total Authors: 13
Affiliation:
[1] Univ Sao Paulo, Sao Carlos Inst Phys, Grp Nanomed & Nanotoxicol, BR-13566590 Sao Carlos - Brazil
[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Pharmaceut, BR-14800903 Araraquara, SP - Brazil
[3] Sao Paulo State Univ UNESP, Inst Chem Araraquara, Dept Physicochem, BR-14800060 Araraquara, SP - Brazil
Total Affiliations: 3
Document type: Review article
Source: Carbohydrate Polymers; v. 250, DEC 15 2020.
Web of Science Citations: 0
Abstract

Chitosan-based particles are widely proposed as biocompatible drug delivery systems with mucoadhesive and permeation enhancing properties. However, strategies on how to modulate the intended biological responses are still scarce. Considering that particle properties affect the biological outcome, the rational design of the synthesis variables should be proposed to engineer drug delivery systems with improved biological performance. The purpose of this review is to establish a deeper understanding of possible correlations between these variables and the particle properties from theoretical and experimental perspectives. The fundamental physicochemical knowledge of chitosan-based polyelectrolyte complexation and surface modification is discussed focusing on chitosan-TPP, polyelectrolyte complexes, and chitosan-surface modified PLGA or lipid particles. A set of design considerations is proposed to enable future investigation in the development of chitosan particles with modulated properties. The approach presented here contributes to the rational design of chitosan-based particles that meet different requirements for biological activities. (AU)

FAPESP's process: 17/16324-0 - Mucoadhesive delivery systems for the release of drugs on intestinal mucosa
Grantee:Maria Palmira Daflon Gremião
Support Opportunities: Regular Research Grants
FAPESP's process: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach
Grantee:Maria Vitória Lopes Badra Bentley
Support Opportunities: Research Projects - Thematic Grants