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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

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Author(s):
Lima, Fabiana da Silva [1] ; Fock, Ricardo Ambrosio [2]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Dept Food & Expt Nutr, Sch Pharmaceut Sci, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Lab Expt Hematol, Dept Clin & Toxicol Anal, Sch Pharmaceut Sci, Ave Lineu Prestes 580, Bloco 17, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 21, n. 19 OCT 2020.
Web of Science Citations: 0
Abstract

Magnesium (Mg2+) is an essential mineral for the functioning and maintenance of the body. Disturbances in Mg2+ intracellular homeostasis result in cell-membrane modification, an increase in oxidative stress, alteration in the proliferation mechanism, differentiation, and apoptosis. Mg2+ deficiency often results in inflammation, with activation of inflammatory pathways and increased production of proinflammatory cytokines by immune cells. Immune cells and others that make up the blood system are from hematopoietic tissue in the bone marrow. The hematopoietic tissue is a tissue with high indices of renovation, and Mg2+ has a pivotal role in the cell replication process, as well as DNA and RNA synthesis. However, the impact of the intra- and extracellular disturbance of Mg2+ homeostasis on the hematopoietic tissue is little explored. This review deals specifically with the physiological requirements of Mg2+ on hematopoiesis, showing various studies related to the physiological requirements and the effects of deficiency or excess of this mineral on the hematopoiesis regulation, as well as on the specific process of erythropoiesis, granulopoiesis, lymphopoiesis, and thrombopoiesis. The literature selected includes studies in vitro, in animal models, and in humans, giving details about the impact that alterations of Mg2+ homeostasis can have on hematopoietic cells and hematopoietic tissue. (AU)

FAPESP's process: 18/25813-8 - Effect of protein malnutrition on hematopoiesis. marrow endothelial cell involvement and action of granulocytic colony stimulating factor (G-CSF)
Grantee:Ricardo Ambrósio Fock
Support Opportunities: Regular Research Grants