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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis

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Author(s):
Scharf, Pablo [1] ; Broering, Milena Fronza [1] ; Oliveira da Rocha, Gustavo Henrique [1] ; Farsky, Sandra Helena Poliselli [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-00550800 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 21, n. 19 OCT 2020.
Web of Science Citations: 0
Abstract

Hematopoiesis is a complex and intricate process that aims to replenish blood components in a constant fashion. It is orchestrated mostly by hematopoietic progenitor cells (hematopoietic stem cells (HSCs)) that are capable of self-renewal and differentiation. These cells can originate other cell subtypes that are responsible for maintaining vital functions, mediate innate and adaptive immune responses, provide tissues with oxygen, and control coagulation. Hematopoiesis in adults takes place in the bone marrow, which is endowed with an extensive vasculature conferring an intense flow of cells. A myriad of cell subtypes can be found in the bone marrow at different levels of activation, being also under constant action of an extensive amount of diverse chemical mediators and enzymatic systems. Bone marrow platelets, mature erythrocytes and leukocytes are delivered into the bloodstream readily available to meet body demands. Leukocytes circulate and reach different tissues, returning or not returning to the bloodstream. Senescent leukocytes, specially granulocytes, return to the bone marrow to be phagocytized by macrophages, restarting granulopoiesis. The constant high production and delivery of cells into the bloodstream, alongside the fact that blood cells can also circulate between tissues, makes the hematopoietic system a prime target for toxic agents to act upon, making the understanding of the bone marrow microenvironment vital for both toxicological sciences and risk assessment. Environmental and occupational pollutants, therapeutic molecules, drugs of abuse, and even nutritional status can directly affect progenitor cells at their differentiation and maturation stages, altering behavior and function of blood compounds and resulting in impaired immune responses, anemias, leukemias, and blood coagulation disturbances. This review aims to describe the most recently investigated molecular and cellular toxicity mechanisms of current major environmental pollutants on hematopoiesis in the bone marrow. (AU)

FAPESP's process: 17/05430-4 - Effects of the interaction between annexin A1 and PPAR gamma upon development of experimental colitis
Grantee:Gustavo Henrique Oliveira da Rocha
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 19/19573-7 - Effects of the hot not burn tobacco exposure on Rheumatoid Arthritis
Grantee:Sandra Helena Poliselli Farsky
Support Opportunities: Regular Research Grants
FAPESP's process: 18/26383-7 - Effects of lipidic nucleus nanocapsule containing Annexin A1 in Ulcerative Colitis model induced in mice
Grantee:Milena Fronza Broering
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/07328-4 - Identification of endogenous pathways for the control of inflammation
Grantee:Sandra Helena Poliselli Farsky
Support Opportunities: Research Projects - Thematic Grants