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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Two polyphenol-rich Brazilian fruit extracts protect from diet-induced obesity and hepatic steatosis in mice

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Author(s):
Ballard, Cintia Reis [1] ; dos Santos, Elisvania Freitas [2] ; Dubois, Marie-Julie [3] ; Pilon, Genevieve [3] ; Betim Cazarin, Cinthia Bau [1] ; Marostica Junior, Mario Roberto [1] ; Marette, Andre [3]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Sch Food Engn, Dept Food & Nutr, 80 Monteiro Lobato, BR-13083862 Campinas, SP - Brazil
[2] Univ Fed Mato Grosso do Sul, Sch Pharmaceut Sci Food & Nutr, S-N Costa & Silva, BR-79070900 Campo Grande, MS - Brazil
[3] Laval Univ, Laval Hosp, Quebec Heart & Lung Inst, 2725 St Foy, Quebec City, PQ G1V 4G5 - Canada
Total Affiliations: 3
Document type: Journal article
Source: FOOD & FUNCTION; v. 11, n. 10, p. 8800-8810, OCT 1 2020.
Web of Science Citations: 0
Abstract

Consumption of polyphenol-rich food is associated with better metabolic health. Tucum-do-Pantanal (Bactris setosa Mart) and taruma-do-cerrado (Vitex cymosa Bertero ex Spreng) are underexploited native Brazilian fruits with an important source of phytochemicals. In this study, we assessed the effects of 100 mg kg(-1)tucum (TPE) and taruma (TCE) extracts on diet-induced obesity (DIO) C57BL/6J mice. After 8 weeks of daily treatment, TPE and TCE were found to significantly prevented the diet-induced body weight gain and fully protected against hepatic steatosis associated with a tendency to stimulate hepatic AMPK phosphorylation. TPE reduced visceral obesity and improved glucose metabolism as revealed by an improvement of the insulin tolerance test, a reduction in the insulin fasting level, and a decreased glucose-induced hyperinsulinemia during an oral glucose tolerance test. TPE and TCE showed promising effects on the treatment of obesity and NAFLD, furthermore, TPE on insulin resistance. (AU)

FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
Grantee:Glaucia Maria Pastore
Support Opportunities: Research Projects - Thematic Grants