Enhancing the Anti-Erosive Properties of Fluoride and Stannous with the Polymer Carbopol

Author(s)

Avila, Daniele Mara da Silva ^[1] ; Augusto, Marina Gullo ^[1] ; Zanatta, Rayssa Ferreira ^{[1, 2]} ; Scaramucci, Tais ^[3] ; Aoki, Idalina Vieira ^[4] ; Torres, Carlos Rocha Gomes ^[1] ; Borges, Alessandra Buhler ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Inst Sci & Technol, Dept Restorat Dent, Ave Engn Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil

^[2] Univ Taubate, Dent Sch, Dept Restorat Dent, Taubate, SP - Brazil

^[3] Sao Paulo Univ USP, Dept Restorat Dent, Sao Paulo, SP - Brazil

^[4] Sao Paulo Univ USP, Polytech Sch, Dept Chem Engn, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Caries Research; v. 54, n. 3, p. 250-257, OCT 2020.
• Web of Science Citations: 0

Abstract

This in vitro study investigated whether Carbopol 980 polymer could potentiate the anti-erosive effect of solutions containing sodium fluoride (F) and sodium fluoride associated with stannous chloride (FS). The dissolution of hydroxyapatite treated with the experimental solutions (F {[}500 ppm F-], F + Carbopol {[}0.1%], FS {[}500 ppm F- + 800 ppm Sn2+], FS + Carbopol) was evaluated. Deionized water was the negative control, and a commercial mouth rinse (AmF/NaF/SnCl2; 500 ppm F + 800 ppm Sn2+; Elmex (R) Erosion Protection) was the positive control. The solutions were also evaluated in an erosion-rehardening protocol, with two treatments per day, using bovine enamel specimens (n= 15) and human saliva. The acid challenge was performed using 0.3% citric acid (pH 2.6) for 2 min. Microhardness was measured at different times: baseline, after the first erosive challenge, after treatment, and after the second erosive challenge. Based on microhardness values, the demineralization, rehardening, and protective potentials were calculated. The alkali-soluble fluoride on enamel surfaces was also measured. Data were analyzed using ANOVA and Tukey tests (alpha = 0.05). Groups treated with FS + Carbopol showed the lowest hydroxyapatite dissolution and the highest rehardening and protective potentials. The measurement of alkali-soluble fluoride on enamel surfaces was also higher in the FS + Carbopol group. Carbopol was able to significantly increase the protective effect of the fluoridated solutions in addition to optimizing the adsorption of fluoride on the enamel surface. (AU)

• FAPESP's process: 16/15755-5 - Anti-erosive effect of solutions containing different polymers
• Grantee: Marina Gullo Augusto
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/19585-4 - Evaluation of the protective effect of fluoride associated to bioadhesive polymer carbopol in the development of erosive wear
• Grantee: Daniele Mara da Silva Ávila Nogueira
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/13799-8 - Antierosive potential of fluoridated solutions associated or not to film-forming polymers
• Grantee: Alessandra Buhler Borges
• Support Opportunities: Regular Research Grants