PCL/beta-AgVO3 nanocomposites obtained by solvent casting as potential antimicrobial biomaterials

Author(s)

de Menezes, Beatriz Rossi Canuto ^[1] ; Montanheiro, Thais Larissa do Amaral ^{[1, 2]} ; Sampaio, Aline da Graca ^[3] ; Koga-Ito, Cristiane Yumi ^[3] ; Thim, Gilmar Patrocinio ^[1] ; Montagna, Larissa Stieven ^[2]

Affiliation

^[1] Technol Inst Aeronaut, Lab Plasmas & Proc, Praca Marechal Eduardo Gomes, 50 Vila Acacias, BR-12228900 Sao Jose Dos Campos, SP - Brazil

^[2] Univ Fed Sao Paulo, Technol Lab Polymers & Biopolymers, Sao Paulo - Brazil

^[3] Sao Paulo State Univ UNESP, Sao Jose dos Campos Inst Sci & Technol, Genoma Lab, Sao Paulo - Brazil

• Document type: Journal article
• Source: Journal of Applied Polymer Science; v. 138, n. 13 OCT 2020.
• Web of Science Citations: 0

Abstract

The adhesion of microorganisms on biomaterials can impair its effective application. The addition of antimicrobial agents is a promising alternative to overcome this limitation. In this work, films of polycaprolactone (PCL) and nanostructured beta-AgVO3 (SV) were produced by solvent casting with 0.1, 0.5, and 1.0 wt% of SV. The effect of SV on the structure of PCL was investigate using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Raman spectroscopy, differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). The antimicrobial activity of the films against Staphylococcus aureus and Escherichia coli was evaluated by the agar diffusion method and by direct contact test. FTIR confirmed the presence of SV into the PCL films, with chemical interaction between them. SEM showed that SV nanorods were well dispersed and with good interfacial adhesion with PCL. XRD diffraction and Raman spectroscopy showed that the presence of SV increased the number of nucleation sites, reducing the size of crystallites and increasing the amorphous domains in the PCL matrix, consequently reducing crystallinity. This behavior was confirmed by DSC, which showed a reduction in the crystallinity with increasing SV content. Films with 1 wt% of SV showed antimicrobial activity against Staphylococcus aureus in direct contact test. (AU)

• FAPESP's process: 17/24873-4 - PHBV and hydroxybutyrate functionalized CNT nanocomposite: kinetic study of crystallization and correlation with mechanical properties
• Grantee: Thaís Larissa do Amaral Montanheiro
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 17/02846-5 - AgVO3/PMMA Nanocomposites: Effect of functionalization with acrilamide on mechanical and antimicrobial properties
• Grantee: Beatriz Rossi Canuto de Menezes Rodrigues
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 18/12035-7 - Mechanical and antimicrobial properties of Ag/PMMA nanocomposite
• Grantee: Gilmar Patrocínio Thim
• Support type: Regular Research Grants