| Full text | |
| Author(s): |
Alexandre, Pamela A.
[1, 2]
;
Reverter, Antonio
[2]
;
Berezin, Roberta B.
[1]
;
Porto-Neto, Laercio R.
[2]
;
Ribeiro, Gabriela
[1]
;
Santana, Miguel H. A.
[3]
;
Ferraz, Jose Bento S.
[1]
;
Fukumasu, Heidge
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, BR-13635900 Pirassununga, SP - Brazil
[2] CSIRO, Agr & Food, Brisbane, Qld 4067 - Australia
[3] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Anim Sci, BR-13635900 Pirassununga, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | GENES; v. 11, n. 9 SEP 2020. |
| Web of Science Citations: | 1 |
| Abstract | |
Long non-coding RNA (lncRNA) can regulate several aspects of gene expression, being associated with complex phenotypes in humans and livestock species. In taurine beef cattle, recent evidence points to the involvement of lncRNA in feed efficiency (FE), a proxy for increased productivity and sustainability. Here, we hypothesized specific regulatory roles of lncRNA in FE of indicine cattle. Using RNA-Seq data from the liver, muscle, hypothalamus, pituitary gland and adrenal gland from Nellore bulls with divergent FE, we submitted new transcripts to a series of filters to confidently predict lncRNA. Then, we identified lncRNA that were differentially expressed (DE) and/or key regulators of FE. Finally, we explored lncRNA genomic location and interactions with miRNA and mRNA to infer potential function. We were able to identify 126 relevant lncRNA for FE inBos indicus, some with high homology to previously identified lncRNA inBos taurusand some possible specific regulators of FE in indicine cattle. Moreover, lncRNA identified here were linked to previously described mechanisms related to FE in hypothalamus-pituitary-adrenal axis and are expected to help elucidate this complex phenotype. This study contributes to expanding the catalogue of lncRNA, particularly in indicine cattle, and identifies candidates for further studies in animal selection and management. (AU) | |
| FAPESP's process: | 17/14707-0 - Multi-tisssue omics analyses to uncover feed efficiency in beef cattle |
| Grantee: | Pâmela Almeida Alexandre |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 15/22276-3 - Systems Biology Approach to Determine Molecular Mechanisms Associated with Feed Efficiency in Nelore Cattle |
| Grantee: | Pâmela Almeida Alexandre |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 14/07566-2 - Genomics applied to ruminant production |
| Grantee: | José Bento Sterman Ferraz |
| Support Opportunities: | Research Projects - Thematic Grants |