| Full text | |
| Author(s): |
Esteves, Eliane
[1]
;
Fongsaran, Chanida
[2]
;
Langohr, Ingeborg M.
[2]
;
Riley, Sean P.
[2, 3, 4]
;
Labruna, Marcelo B.
[5]
;
Daffre, Sirlei
[1]
;
Fogaca, Andrea C.
[1]
;
Macaluso, Kevin R.
[2, 6]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, BR-05508900 Sao Paulo - Brazil
[2] Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Baton Rouge, LA 70803 - USA
[3] Univ Maryland, Dept Vet Med, College Pk, MD 20742 - USA
[4] Virginia Maryland Coll Vet Med, College Pk, MD 20742 - USA
[5] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Prevent Vet Med & Anim Hlth, BR-05508270 Sao Paulo - Brazil
[6] Univ S Alabama, Dept Microbiol & Immunol, Coll Med, Mobile, AL 36688 - USA
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | PATHOGENS; v. 9, n. 9 SEP 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Rocky Mountain spotted fever (RMSF) is a life-threatening tick-borne disease caused byRickettsia rickettsii, which is widely distributed throughout the Americas. Over 4000 cases of RMSF are recorded annually in the United States, while only around 100 cases are reported in Brazil. Conversely, while case fatality rates in the United States oscillate around 5%, in Brazil they can surpass 70%, suggesting that differences in tick vectoring capacity, population sensitivity, and/or variability in virulence of the rickettsial strains may exist. In this study, we compared the susceptibility of C3H/HeN mice to two highly virulent strains ofR. rickettsii, one from the United States (Sheila Smith) and the other from Brazil (Taiacu). Animals inoculated with the Taiacu strain succumbed to infection earlier and exhibited severe histological lesions in both liver and spleen sooner than mice infected with the Sheila Smith strain. These differences in survival and signs of the disease are not related to a greater proliferation of the Taiacu strain, as there were no significant differences in the rickettsial load in mice tissues inoculated with either strain. The present study is the first step to experimentally assess differences in fatality rates of RMSF in two different regions of the American continent. (AU) | |
| FAPESP's process: | 13/26450-2 - Molecular characterization of the interactions among ticks, rickettsiae and vertebrate hosts |
| Grantee: | Sirlei Daffre |
| Support Opportunities: | Research Projects - Thematic Grants |