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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Voriconazole-natural latex dressings for treating infected Candida spp. skin ulcers

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Author(s):
da Silva, V, Thaina ; de Barros, Natan R. [1, 2] ; Costa-Orlandi, Caroline B. [1] ; Tanaka, Jean L. [1] ; Moro, Lincoln G. [1] ; Pegorin, Giovana S. [1, 2] ; Oliveira, Kassandra S. M. [3] ; Mendes-Gianinni, Maria J. S. [1] ; Fusco-Almeida, Aria M. [1] ; Herculano, Rondinelli D. [1]
Total Authors: 10
Affiliation:
[1] da Silva, Thaina, V, Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Biotechnol & Bioproc Engn Dept, BR-14800903 Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Chem, Biochem & Chem Technol Dept, BR-14800060 Araraquara, SP - Brazil
[3] Sao Paulo State Univ UNESP, Sch Agr, Rural Engn & Socioecon Dept, BR-18610034 Botucatu, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: FUTURE MICROBIOLOGY; v. 15, n. 15, p. 1439-1452, OCT 2020.
Web of Science Citations: 0
Abstract

Aim: This work aimed to develop a membrane based on voriconazole (VCZ)-loaded natural rubber latex (NRL) for treating infected ulcers with Candida spp. and study their interaction, drug release, antifungal activity against Candida parapsilosis and biological characterization. Materials \& methods: VCZ-loaded NRL membrane was produced by casting method. Results: Infrared spectrum showed that the incorporation of VCZ into the NRL membrane maintained its characteristics. Its mechanical properties were considered suitable for dermal application. The VCZ was able to release from NRL membrane, maintaining its antifungal activity against C. parapsilosis, besides did not present hemolytic effects. Conclusion: The VCZ-NRL membrane showed good results in mechanical, antifungal and biological assays, representing an interesting alternative to treatment of infected wound with Candida spp. Lay abstract Aim: The aim of this work was to develop a membrane from natural rubber latex (NRL) containing an antifungal for the treatment of infected ulcers with Candida spp. and study their interaction, drug release, antifungal activity against Candida parapsilosis and effects on red blood cells. Materials \& methods: The membrane was produced by mixing voriconazole (VCZ) and NRL on a plate. Results: It was shown that the incorporation of VCZ maintained its physical-chemical characteristics, which were considered suitable for dermal application. The VCZ was released from membrane, preserving antifungal activity against C. parapsilosis, besides did not damage the red blood cells membrane. Conclusion: The VCZ-NRL membrane showed good results being an alternative to treatment of infected wound with Candida spp. (AU)

FAPESP's process: 17/19603-8 - Development of a novel patch containing latex and barbatimam e fractions and study of signaling pathways in cutaneous wound repair
Grantee:Rondinelli Donizetti Herculano
Support Opportunities: Regular Research Grants
FAPESP's process: 17/18388-6 - Role of biofilm in the pathogenesis of dermatophytosis and development of combat strategies
Grantee:Caroline Barcelos Costa Orlandi
Support Opportunities: Scholarships in Brazil - Post-Doctoral