Alternative treatment of fungal infections: Synergy with non-antifungal agents

Author(s)

Rossato, Luana ^[1] ; dos Santos, Marielle Camargo ^[2] ; Vitale, Roxana G. ^{[3, 4]} ; de Hoog, Sybren ^[5] ; Ishida, Kelly ^[6]

Affiliation

^[1] Fed Univ Grande Dourados, Fac Ciencias Saude, Rodovia Dourados Itahum, Km 12 Unidade 2, BR-79804970 Dourados, MS - Brazil

^[2] Univ Fed Sao Paulo, Special Lab Mycol, Sao Paulo - Brazil

^[3] Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF - Argentina

^[4] Hosp JM Ramos Mejia, Buenos Aires, DF - Argentina

^[5] Radboud Univ Nijmegen, Canisius Wilhelmina Hosp, Ctr Expertise Mycol, Med Ctr, Nijmegen - Netherlands

^[6] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Lab Antifungal Chemotherapy, Sao Paulo - Brazil

• Document type: Journal article
• Source: MYCOSES; v. 64, n. 3 NOV 2020.
• Web of Science Citations: 0

Abstract

Fungal infections are responsible for high mortality rates in immunocompromised and high-risk surgical patients. Therapy failures during the last decades due to increasing multidrug resistance demand innovative strategies for novel and effective antifungal drugs. Synergistic combinations of antifungals with non-antifungal agents highlight a pragmatic strategy to reduce the development of drug resistance and potentially repurpose known compounds with other functions to bypass costly and time-consuming novel drug development. (AU)

• FAPESP's process: 17/19374-9 - Echinocandins in the control of infections associated to polymicrobial biofilms of Candida spp. and bacteria such as Stapholococcus aureus and Pseudomonas aeruginosa
• Grantee: Kelly Ishida
• Support Opportunities: Regular Research Grants