| Full text | |
| Author(s): |
Soares, Ciro Dantas
[1]
;
Hernandez-Guerrero, Juan Carlos
[2]
;
Benevenuto de Andrade, Bruno Augusto
[1]
;
Romanach, Mario Jose
[3]
;
Mosqueda-Taylor, Adalberto
[4]
;
Carlos, Roman
[5]
;
Soares Macedo, Madja Ruanna
[6]
;
de Almeida, Oslei Paes
[1]
;
Jorge, Jacks
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Estadual Campinas, Dept Oral Diag, Piracicaba Dent Sch, Ave Limeira 901, BR-13414903 Piracicaba, SP - Brazil
[2] Natl Univ Autonomous Mexico, Immunol Lab, Fac Dent, Mexico City, DF - Mexico
[3] Fed Univ Rio de Janeiro UFRJ, Sch Dent, Oral Pathol, Rio De Janeiro - Brazil
[4] Univ Autonoma Metropolitana, Hlth Care Dept, Xochimilco - Mexico
[5] Hosp Herrera Llerandi, Ctr Clin Cabeza & Cuello, Pathol Div, Guatemala City - Guatemala
[6] Univ Fed Rio Grande do Norte, Dept Nursing, Natal, RN - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL; v. 25, n. 6, p. E728-E731, NOV 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Background: Oral melanomas have some histopathological resemblance with its cutaneous counterpart; however, an aggressive behavior is more common in tumors that occur in the oral cavity. Several markers have been suggested as indicative of tumoral progression and aggressiveness, such as cyclooxygenase 2 (COX-2) and Ki67. Material and Methods: In this study, we have compared the expression of COX-2 and Ki67 in a series of amelanotic (n=7) and melanotic oral melanomas (n=22). The cases were selected from 4 pathology laboratories and submitted to the immunohistochemical (IHC) reactions. We analyzed the IHC staining based on a qualitative - using visual scores; and a computer-assisted method (quantitative) using scanned slides and software for digital analysis. Results: COX-2 was expressed in all oral melanomas; however, its intensity was significantly higher in the amelanotic ones (P<0.001). Similarly, a high Ki67-positivity index was observed in the amelanotic than melanotic ones (P<0.001). Conclusions: Based on these results, we suggest that amelanotic oral melanomas have marked pro-inflammatory and high-proliferative phenotype, justifying their more aggressive behavior compared with the melanotic ones. (AU) | |
| FAPESP's process: | 15/25905-1 - Akt, COX-2, RUNX1 and MMPs expression in metastatic melanomas and Biotechnology prospection of molecules with antineoplastic activity |
| Grantee: | Ciro Dantas Soares |
| Support Opportunities: | Scholarships in Brazil - Doctorate |