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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exercise Reduces the Resumption of Tumor Growth and Proteolytic Pathways in the Skeletal Muscle of Mice Following Chemotherapy

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Alves de Lima, Jr., Edson [1] ; Teixeira, Alexandre Abilio de Souza [1] ; Biondo, Luana Amorim [1] ; Diniz, Tiego Aparecido [1] ; Silveira, Loreana Sanches [1] ; Coletti, Dario [2, 3] ; Busquets Rius, Silvia [4] ; Rosa Neto, Jose Cesar [1]
Total Authors: 8
[1] Univ Sao Paulo, Dept Cell & Dev Biol, Immunometab Res Grp, BR-05508000 Sao Paulo - Brazil
[2] Sorbonne Univ, CNRS, Biol Adaptat & Ageing, INSERM, ERL, U1164, UMR 8256, B2A, F-75005 Paris - France
[3] Sapienza Univ Rome, Dept Anat Histol Forens Med & Orthoped, I-00185 Rome - Italy
[4] Univ Barcelona, Fac Biol, Dept Bioquim & Mol Biomed, Canc Res Grp, Barcelona 08028 - Spain
Total Affiliations: 4
Document type: Journal article
Source: CANCERS; v. 12, n. 11 NOV 2020.
Web of Science Citations: 0

Simple Summary Doxorubicin is a chemotherapeutic agent that contributes to muscle wasting. Based on the evidence that many cancer variants are associated with cachexia and that cancer patients are usually treated with chemotherapeutic agents, it is important to determine strategies to mitigate muscle atrophy. Muscle loss is a poor prognosis during cancer treatment, and exercise has emerged as a potential strategy utilized in this context. Once an ongoing regimen of chemotherapeutic treatment is not always possible, our results demonstrated that continuity of endurance exercise is a potential strategy that can be adopted when chemotherapy needs to be interrupted, minimizing the resumption of tumor growth and avoiding muscle loss. The pathogenesis of muscle atrophy plays a central role in cancer cachexia, and chemotherapy contributes to this condition. Therefore, the present study aimed to evaluate the effects of endurance exercise on time-dependent muscle atrophy caused by doxorubicin. For this, C57 BL/6 mice were subcutaneously inoculated with Lewis lung carcinoma cells (LLC group). One week after the tumor establishment, a group of these animals initiated the doxorubicin chemotherapy alone (LLC + DOX group) or combined with endurance exercise (LLC + DOX + EXER group). One group of animals was euthanized after the chemotherapy cycle, whereas the remaining animals were euthanized one week after the last administration of doxorubicin. The practice of exercise combined with chemotherapy showed beneficial effects such as a decrease in tumor growth rate after chemotherapy interruption and amelioration of premature death due to doxorubicin toxicity. Moreover, the protein degradation levels in mice undergoing exercise returned to basal levels after chemotherapy; in contrast, the mice treated with doxorubicin alone experienced an increase in the mRNA expression levels of the proteolytic pathways in gastrocnemius muscle (Trim63, Fbxo32, Myostatin, FoxO). Collectively, our results suggest that endurance exercise could be utilized during and after chemotherapy for mitigating muscle atrophy promoted by doxorubicin and avoid the resumption of tumor growth. (AU)

FAPESP's process: 15/17068-2 - Effect of aerobic exercise training associated with doxorubicin chemotherapy in mice with Lewis lung carcinoma (LLC). Role of adiponectin in skeletal muscle and tumor.
Grantee:Edson Alves de Lima Junior
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/09367-4 - Metabolic effects of doxorubicin on the muscle and adipose tissue: do exercise and metformin reduce the damage?
Grantee:José Cesar Rosa Neto
Support type: Regular Research Grants
FAPESP's process: 19/01244-7 - Pharmacological and non-pharmacological management of muscle wasting
Grantee:Edson Alves de Lima Junior
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 19/09854-9 - Effect of doxorubicin upon the adipose tissue: elucidation the role of PPARs family
Grantee:José Cesar Rosa Neto
Support type: Regular Research Grants