Applications of Non-invasive Neuromodulation for the Management of Disorders Related to COVID-19

Author(s):Show less -

Baptista, Abrahao Fontes ^{[1, 2, 3, 4]} ; Baltar, Adriana ^{[2, 5]} ; Okano, Alexandre Hideki ^{[1, 6, 2, 3]} ; Moreira, Alexandre ^[7] ; Campos, Ana Carolina Pinheiro ^[8] ; Fernandes, Ana Mercia ^[9] ; Brunoni, Andre Russowsky ^{[10, 11]} ; Badran, Bashar W. ^[12] ; Tanaka, Clarice ^{[2, 13]} ; de Andrade, Daniel Ciampi ^{[2, 9]} ; da Silva Machado, Daniel Gomes ^[14] ; Morya, Edgard ^[15] ; Trujillo, Eduardo ^{[1, 2]} ; Swami, Jaiti K. ^[16] ; Camprodon, Joan A. ^{[17, 18]} ; Monte-Silva, Katia ^{[2, 19]} ; Sa, Katia Nunes ^{[20, 2, 21]} ; Nunes, Isadora ; Goulardins, Juliana Barbosa ^{[7, 2, 4, 22]} ; Bikson, Marom ^[16] ; Sudbrack-Oliveira, Pedro ^[23] ; de Carvalho, Priscila ^[13] ; Duarte-Moreira, Rafael Jardim ^{[1, 2]} ; Pagano, Rosana Lima ^[8] ; Shinjo, Samuel Katsuyuki ^[24] ; Zana, Yossi ^[1]

Affiliation:Show less -

^[1] Fed Univ ABC, Ctr Math Computat & Cognit, Sao Bernardo Do Campo - Brazil

^[2] NAPeN Network Rede Nucleos Assistencia & Pesquisa, Sao Bernardo Do Campo - Brazil

^[3] Univ Estadual Campinas, Brazilian Inst Neurosci & Neurotechnol, Ctr Pesquisa Invest & Difusao, Fundacao Amparo Pesquisa Estado Sao Paulo BRAINN, Campinas - Brazil

^[4] Univ Sao Paulo, Lab Med Invest 54 LIM 54, Sao Paulo - Brazil

^[5] Specialized Neuromodulat Ctr Neuromod, Recife, PE - Brazil

^[6] Univ Estadual Londrina, Grad Program Phys Educ, Londrina, Parana - Brazil

^[7] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil

^[8] Hosp Sirio Libanes, Lab Neurosci, Sao Paulo - Brazil

^[9] Univ Sao Paulo, Fac Med FMUSP, Dept Neurol, Ctr Dor, LIM62, Sao Paulo - Brazil

^[10] Inst Nacl Biomarcadores Neuropsiquiatria, Lab Neurociencias LIM 27, Serv Interdisciplinar Neuromodulacao, Sao Paulo - Brazil

^[11] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Inst Psiquiatria, Sao Paulo - Brazil

^[12] Med Univ South Carolina, Dept Psychiat, Charleston, SC 29425 - USA

^[13] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Inst Cent, Sao Paulo - Brazil

^[14] Univ Fed Rio Grande do Norte, Grad Program Collect Hlth, Natal, RN - Brazil

^[15] Santos Dumont Inst, Edmond & Lily Safra Int Neurosci Inst, Macaiba - Brazil

^[16] CUNY, City Coll New York, Dept Biomed Engn, New York, NY 10031 - USA

^[17] Harvard Med Sch, Boston, MA 02115 - USA

^[18] Massachusetts Gen Hosp, Lab Neuropsychiat & Neuromodulat, Boston, MA 02114 - USA

^[19] Univ Fed Pernambuco, Appl Neurosci Lab, Recife, PE - Brazil

^[20] Escola Bahiana Med & Saude Publ, Salvador, BA - Brazil

^[21] Pontificia Univ Catolica Minas Gerais, Dept Physiotherapy, Betim - Brazil

^[22] Univ Cruzeiro Sul UNICSUL, Sao Paulo - Brazil

^[23] Univ Sao Paulo, Fac Med FMUSP, Sao Paulo - Brazil

^[24] Univ Sao Paulo, Fac Med FMUSP, Div Rheumatol, Sao Paulo - Brazil

• Document type: Review article
• Source: FRONTIERS IN NEUROLOGY; v. 11, NOV 25 2020.
• Web of Science Citations: 0

Abstract

Background: Novel coronavirus disease (COVID-19) morbidity is not restricted to the respiratory system, but also affects the nervous system. Non-invasive neuromodulation may be useful in the treatment of the disorders associated with COVID-19. Objective: To describe the rationale and empirical basis of the use of non-invasive neuromodulation in the management of patients with COVID-10 and related disorders. Methods: We summarize COVID-19 pathophysiology with emphasis of direct neuroinvasiveness, neuroimmune response and inflammation, autonomic balance and neurological, musculoskeletal and neuropsychiatric sequela. This supports the development of a framework for advancing applications of non-invasive neuromodulation in the management COVID-19 and related disorders. Results: Non-invasive neuromodulation may manage disorders associated with COVID-19 through four pathways: (1) Direct infection mitigation through the stimulation of regions involved in the regulation of systemic anti-inflammatory responses and/or autonomic responses and prevention of neuroinflammation and recovery of respiration; (2) Amelioration of COVID-19 symptoms of musculoskeletal pain and systemic fatigue; (3) Augmenting cognitive and physical rehabilitation following critical illness; and (4) Treating outbreak-related mental distress including neurological and psychiatric disorders exacerbated by surrounding psychosocial stressors related to COVID-19. The selection of the appropriate techniques will depend on the identified target treatment pathway. Conclusion: COVID-19 infection results in a myriad of acute and chronic symptoms, both directly associated with respiratory distress (e.g., rehabilitation) or of yet-to-be-determined etiology (e.g., fatigue). Non-invasive neuromodulation is a toolbox of techniques that based on targeted pathways and empirical evidence (largely in non-COVID-19 patients) can be investigated in the management of patients with COVID-19. (AU)

• FAPESP's process: 19/10760-9 - Circadian variability of motor cortex excitability in patients with Mesial Temporal Lobe Epilepsy: a Transcranial Magnetic Stimulation (TMS) study
• Grantee: Pedro Sudbrack Oliveira
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 18/18695-9 - Deep brain stimulation and Parkinsons Disease: neuroinflammation control as therapeutic target
• Grantee: Ana Carolina Pinheiro Campos
• Support type: Scholarships in Brazil - Doctorate (Direct)