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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Applications of Non-invasive Neuromodulation for the Management of Disorders Related to COVID-19

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Author(s):
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Baptista, Abrahao Fontes [1, 2, 3, 4] ; Baltar, Adriana [2, 5] ; Okano, Alexandre Hideki [1, 6, 2, 3] ; Moreira, Alexandre [7] ; Campos, Ana Carolina Pinheiro [8] ; Fernandes, Ana Mercia [9] ; Brunoni, Andre Russowsky [10, 11] ; Badran, Bashar W. [12] ; Tanaka, Clarice [2, 13] ; de Andrade, Daniel Ciampi [2, 9] ; da Silva Machado, Daniel Gomes [14] ; Morya, Edgard [15] ; Trujillo, Eduardo [1, 2] ; Swami, Jaiti K. [16] ; Camprodon, Joan A. [17, 18] ; Monte-Silva, Katia [2, 19] ; Sa, Katia Nunes [20, 2, 21] ; Nunes, Isadora ; Goulardins, Juliana Barbosa [7, 2, 4, 22] ; Bikson, Marom [16] ; Sudbrack-Oliveira, Pedro [23] ; de Carvalho, Priscila [13] ; Duarte-Moreira, Rafael Jardim [1, 2] ; Pagano, Rosana Lima [8] ; Shinjo, Samuel Katsuyuki [24] ; Zana, Yossi [1]
Total Authors: 26
Affiliation:
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[1] Fed Univ ABC, Ctr Math Computat & Cognit, Sao Bernardo Do Campo - Brazil
[2] NAPeN Network Rede Nucleos Assistencia & Pesquisa, Sao Bernardo Do Campo - Brazil
[3] Univ Estadual Campinas, Brazilian Inst Neurosci & Neurotechnol, Ctr Pesquisa Invest & Difusao, Fundacao Amparo Pesquisa Estado Sao Paulo BRAINN, Campinas - Brazil
[4] Univ Sao Paulo, Lab Med Invest 54 LIM 54, Sao Paulo - Brazil
[5] Specialized Neuromodulat Ctr Neuromod, Recife, PE - Brazil
[6] Univ Estadual Londrina, Grad Program Phys Educ, Londrina, Parana - Brazil
[7] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil
[8] Hosp Sirio Libanes, Lab Neurosci, Sao Paulo - Brazil
[9] Univ Sao Paulo, Fac Med FMUSP, Dept Neurol, Ctr Dor, LIM62, Sao Paulo - Brazil
[10] Inst Nacl Biomarcadores Neuropsiquiatria, Lab Neurociencias LIM 27, Serv Interdisciplinar Neuromodulacao, Sao Paulo - Brazil
[11] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Inst Psiquiatria, Sao Paulo - Brazil
[12] Med Univ South Carolina, Dept Psychiat, Charleston, SC 29425 - USA
[13] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Inst Cent, Sao Paulo - Brazil
[14] Univ Fed Rio Grande do Norte, Grad Program Collect Hlth, Natal, RN - Brazil
[15] Santos Dumont Inst, Edmond & Lily Safra Int Neurosci Inst, Macaiba - Brazil
[16] CUNY, City Coll New York, Dept Biomed Engn, New York, NY 10031 - USA
[17] Harvard Med Sch, Boston, MA 02115 - USA
[18] Massachusetts Gen Hosp, Lab Neuropsychiat & Neuromodulat, Boston, MA 02114 - USA
[19] Univ Fed Pernambuco, Appl Neurosci Lab, Recife, PE - Brazil
[20] Escola Bahiana Med & Saude Publ, Salvador, BA - Brazil
[21] Pontificia Univ Catolica Minas Gerais, Dept Physiotherapy, Betim - Brazil
[22] Univ Cruzeiro Sul UNICSUL, Sao Paulo - Brazil
[23] Univ Sao Paulo, Fac Med FMUSP, Sao Paulo - Brazil
[24] Univ Sao Paulo, Fac Med FMUSP, Div Rheumatol, Sao Paulo - Brazil
Total Affiliations: 24
Document type: Review article
Source: FRONTIERS IN NEUROLOGY; v. 11, NOV 25 2020.
Web of Science Citations: 0
Abstract

Background: Novel coronavirus disease (COVID-19) morbidity is not restricted to the respiratory system, but also affects the nervous system. Non-invasive neuromodulation may be useful in the treatment of the disorders associated with COVID-19. Objective: To describe the rationale and empirical basis of the use of non-invasive neuromodulation in the management of patients with COVID-10 and related disorders. Methods: We summarize COVID-19 pathophysiology with emphasis of direct neuroinvasiveness, neuroimmune response and inflammation, autonomic balance and neurological, musculoskeletal and neuropsychiatric sequela. This supports the development of a framework for advancing applications of non-invasive neuromodulation in the management COVID-19 and related disorders. Results: Non-invasive neuromodulation may manage disorders associated with COVID-19 through four pathways: (1) Direct infection mitigation through the stimulation of regions involved in the regulation of systemic anti-inflammatory responses and/or autonomic responses and prevention of neuroinflammation and recovery of respiration; (2) Amelioration of COVID-19 symptoms of musculoskeletal pain and systemic fatigue; (3) Augmenting cognitive and physical rehabilitation following critical illness; and (4) Treating outbreak-related mental distress including neurological and psychiatric disorders exacerbated by surrounding psychosocial stressors related to COVID-19. The selection of the appropriate techniques will depend on the identified target treatment pathway. Conclusion: COVID-19 infection results in a myriad of acute and chronic symptoms, both directly associated with respiratory distress (e.g., rehabilitation) or of yet-to-be-determined etiology (e.g., fatigue). Non-invasive neuromodulation is a toolbox of techniques that based on targeted pathways and empirical evidence (largely in non-COVID-19 patients) can be investigated in the management of patients with COVID-19. (AU)

FAPESP's process: 19/10760-9 - Circadian variability of motor cortex excitability in patients with Mesial Temporal Lobe Epilepsy: a Transcranial Magnetic Stimulation (TMS) study
Grantee:Pedro Sudbrack Oliveira
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/18695-9 - Deep brain stimulation and Parkinsons Disease: neuroinflammation control as therapeutic target
Grantee:Ana Carolina Pinheiro Campos
Support type: Scholarships in Brazil - Doctorate (Direct)