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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development and characterization of a novel liquid crystalline system containing sodium alginate for incorporation of trans-resveratrol intended for treatment of buccal candidiasis

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Author(s):
Miyashiro, C. A. [1] ; Bernegossi, J. [1] ; Bonifacio, V, B. ; de Toledo, L. G. [2] ; Ramos, M. A. S. [2] ; Bauab, T. M. [2] ; Chorilli, M. [2]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Araraquara, SP - Brazil
[2] Bonifacio, B., V, Sao Paulo State Univ Unesp, Sch Pharmaceut Sci, Araraquara, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Pharmazie; v. 75, n. 5, p. 179-185, MAY 2020.
Web of Science Citations: 2
Abstract

Trans-resveratrol has antimicrobial effects; however, its hydrophobic properties hamper its incorporation into pharmaceutical formulations. The aim of this study was to develop liquid crystals and a liquid crystal precursor (microemulsion), a common nanotechnology-based drug delivery system using a surfactant, an oil phase, and a polymer dispersion, for topical administration against buccal candidiasis. A ternary diagram was constructed and a potential formulation was selected, in order to run characterization tests. We chose the formulation that presented microemulsion and crystal liquid characteristics through polarized light microscopy and small-angle X-ray scattering experiments. The stability and structural features of the formulations were observed by performing rheological assay, measuring mucoadhesion, and analyzing texture profiles. It was verified that the chosen system was capable of transiting from microemulsion to liquid crystals when added in aqueous phase; further, the presence of sodium alginate as the polymer increased its mucoadhesion strength. Microbiological assay of trans-resveratrol, using amphotericin B and fluconazole as controls against strains of Candida albicans, showed positive anti-microbiological effect; however, a high concentration of the compound was needed. (AU)

FAPESP's process: 14/22045-9 - Mucoadhesive precursor systems of liquids crystals for buccal administration of curcumin associated with photodynamic therapy in the treatment of oral candidiasis
Grantee:Jéssica Bernegossi
Support Opportunities: Scholarships in Brazil - Doctorate